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PLTP Protein, Human, Recombinant (His), Biotinylated

产品编号 TMPY-06100

别名: BPIFE, phospholipid transfer protein, HDLCQ9

PLTP Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.5 kDa and the accession number is P55058-1.

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PLTP Protein, Human, Recombinant (His), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 3,170		5日内发货
100 μg	￥ 7,160		5日内发货

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生物活性	Testing in progress
产品描述	PLTP Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.5 kDa and the accession number is P55058-1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P55058-1
别名	BPIFE, phospholipid transfer protein, HDLCQ9
蛋白构建	The Human PLTP isoform 1 (P55058-1) (Met1-Val493) was expressed, fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 80 % as determined by SDS-PAGE
分子量	54.5 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Phospholipid transfer protein, also known as Lipid transfer protein II and PLTP, is a secreted protein that belongs to the BPI/LBP/Plunc superfamily and BPI / LBP family. PLTP is nearly ubiquitously expressed in cells and tissues. PLTP converts HDL into larger and smaller particles. It may play a key role in extracellular phospholipid transport and modulation of hdl particles. High-density lipoproteins (HDL) play a major protective role against the development of coronary artery disease. PLTP is a main factor regulating the size and composition of HDL in the circulation and plays an important role in controlling plasma HDL levels. This is achieved via both the phospholipid transfer activity of PLTP and its capability to cause HDL conversion. PLTP is one of the key lipid transfer proteins in plasma and cerebrospinal fluid. It is involved in novel intracellular functions. PLTP is an important modulator of lipoprotein metabolism, including interparticle phospholipid transfer, remodeling of HDL, cholesterol and phospholipid efflux from peripheral tissues, and the production of hepatic VLDL. PLTP also plays an important role in inflammation and oxidative stress. Accordingly, PLTP has also been implicated in the development of atherosclerosis.

参考文献

1. Huuskonen, J. et al., 2000, Atherosclerosis. 151 (2): 451-61. 2. Huuskonen,J. et al., 2001, Atherosclerosis. 155 (2): 269-81. 3. Valenta,D.T. et al., 2008, J Lipid Res. 49 (1): 24-32. 4. Vuletic,S. et al., 2009, Biochim Biophys Acta. 1793 (3): 584-91. 5. Chen, X. et al., 2009, Nutr Metab. 6 : 49.

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Keywords

PLTP Protein, Human, Recombinant (His), Biotinylated BPIFE HDLCQ-9 phospholipid transfer protein HDLCQ9 HDLCQ 9 recombinant recombinant-proteins proteins protein

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