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Cernuumolide J (TMJ-105),作为JAK2/STAT3抑制剂,有效调节多种关键磷酸化通路。通过降低JAK2、STAT3和Erk的磷酸化水平,并增强JNK与p38 MAPK的磷酸化活性,该化合物能够诱导HEL白血病细胞在G2/M期产生阻滞并触发细胞凋亡(Apoptosis)。此外,Cernuumolide J显示出对HEL白血病细胞生长的抑制作用呈时间和浓度依赖性,其IC50值达到1.79 μM,表明其在抗癌研究领域的潜在应用价值。
Cernuumolide J (TMJ-105),作为JAK2/STAT3抑制剂,有效调节多种关键磷酸化通路。通过降低JAK2、STAT3和Erk的磷酸化水平,并增强JNK与p38 MAPK的磷酸化活性,该化合物能够诱导HEL白血病细胞在G2/M期产生阻滞并触发细胞凋亡(Apoptosis)。此外,Cernuumolide J显示出对HEL白血病细胞生长的抑制作用呈时间和浓度依赖性,其IC50值达到1.79 μM,表明其在抗癌研究领域的潜在应用价值。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy. |
别名 | TMJ-105 |
分子量 | 450.52 |
分子式 | C24H34O8 |
CAS No. | 2019163-02-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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