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CTLA-4 Protein, Human, Recombinant (hFc)

产品编号 TMPY-05002

别名: CD, cytotoxic T-lymphocyte-associated protein 4, IDDM12, ALPS5, CD152, GSE, GRD4, CELIAC3, CTLA-4

CTLA-4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is P16410-1.

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CTLA-4 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 500		5日内发货
1 mg	￥ 5,000		5日内发货

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参考文献

生物活性	Loaded Recombinant Human CTLA-4 Protein, hFc Tag on ProA Biosensor, can bind Recombinant Human B7-1 Protein, His Tag with an affinity constant of 5.331nM as determined in BLI assay (Routinely tested).
产品描述	CTLA-4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is P16410-1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P16410-1
别名	CD, cytotoxic T-lymphocyte-associated protein 4, IDDM12, ALPS5, CD152, GSE, GRD4, CELIAC3, CTLA-4
蛋白构建	The Human CTLA4 (NP_005205.2) (Met1-Phe162) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	40.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsCTLA4 / CD152 Immune Checkpoint ProteinsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Slavik JM,et al.(1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24. 2. Holmberg D,et al.(2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33. 3. Chin LT,et al.(2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.

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Keywords

CTLA-4 Protein, Human, Recombinant (hFc) CD cytotoxic T-lymphocyte-associated protein 4 CTLA 4 IDDM-12 IDDM12 ALPS-5 CELIAC-3 ALPS5 CELIAC 3 CD152 GSE GRD-4 CD 152 IDDM 12 GRD4 CD-152 CELIAC3 GRD 4 ALPS 5 CTLA-4 CTLA4 recombinant recombinant-proteins proteins protein

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