Ravoxertinib hydrochloride

产品编号 T15377Cas号 2070009-58-2

别名 GDC-0994 (hydrochloride)

Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).

Ravoxertinib hydrochloride

产品编号 T15377别名 GDC-0994 (hydrochloride)Cas号 2070009-58-2

Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).

规格	价格	库存
2 mg	¥ 824	5日内发货
5 mg	¥ 1,410	5日内发货
25 mg	¥ 4,800	8-10周
50 mg	¥ 6,240	8-10周
100 mg	¥ 9,620	8-10周

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产品介绍

生物活性

产品描述	Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
靶点活性	ERK2:3.1 nM, p-RSK:12 nM, ERK1:6.1 nM
体外活性	Ravoxertinib inhibits p90RSK (IC50: 12 nM) [1]. Ravoxertinib is highly selective for ERK1 and ERK2 (biochemical potency: 1.1 nM and 0.3 nM, respectively) [2].
体内活性	Ravoxertinib (10 mg/kg; p.o.; in CD-1 mice) is sufficient to achieve the desired target coverage for at least 8 h [1]. Ravoxertinib (p.o.; daily) causes significant single-agent activity in multiple in vivo cancer models, including KRAS-mutant and BRAF-mutant human xenograft tumors in mice [2].
别名	GDC-0994 (hydrochloride)

化学信息

分子量	477.32
分子式	C₂₁H₁₉Cl₂FN₆O₂
CAS No.	2070009-58-2

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (209.50 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0950 mL	10.4752 mL	20.9503 mL	104.7515 mL
5 mM	0.4190 mL	2.0950 mL	4.1901 mL	20.9503 mL
10 mM	0.2095 mL	1.0475 mL	2.0950 mL	10.4752 mL
20 mM	0.1048 mL	0.5238 mL	1.0475 mL	5.2376 mL
50 mM	0.0419 mL	0.2095 mL	0.4190 mL	2.0950 mL
100 mM	0.0210 mL	0.1048 mL	0.2095 mL	1.0475 mL