流感病毒蛋白 (Influenza Proteins)

Influenza A H1N1 (A Michigan 45 2015) Neuraminidase NA (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.2 kDa.

Influenza A H1N1 (A New York 1 1918) Hemagglutinin Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.5 kDa and the accession number is Q9WFX4.

Influenza B (B Austria 1359417 2021) Nucleoprotein NP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 63 kDa.

Influenza A H5N1 (A Cambodia R0405050 2007) Hemagglutinin HA Protein (HA1+HA2, uncleaved, GRRKKR to TETR, aa 1-531, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is B6EBW8.

Influenza A H5N1 (A VietNam 1203 2004) Hemagglutinin HA Protein (His & Fc) is expressed in HEK293 mammalian cells with His and Fc tag. The predicted molecular weight is 85.7 kDa and the accession number is Q5EP31.

Influenza A H1N1 (A Puerto Rico 8 1934) Hemagglutinin HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is P03452.

Influenza A H3N2 (A Victoria 361 2011) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is L0HR89.

Influenza A H7N9 (A Anhui 1 2013) Hemagglutinin HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa.

Influenza A H1N1 (A Beijing 22808 2009) Hemagglutinin HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is D3YSI0.

Influenza A H1N1 (A WSN 1933) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is B4URE7.

Influenza A H1N1 (A Texas 36 1991) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is B4UPL3.

Influenza A H7N1 (A turkey Italy 4602 99) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q7TAW6.

Influenza A H11N2 (A thick-billed murre Newfoundland 031 2007) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.4 kDa.

Influenza A H13N8 (A black-headed gull Netherlands 1 00) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58.5 kDa and the accession number is Q5DL26.

Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. Human parainfluenza 1 virus (HPIV-1) Nucleoprotein NP Protein (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.6 kDa and the accession number is P24304.

Influenza A H5N1 (A chicken VietNam NCVD-016 2008) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is C4P278.

Influenza A H6N2 (A chicken Guangdong C273 2011) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.6 kDa and the accession number is I6PXD2.

Influenza A H3N2 (A Moscow 10 1999) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.3 kDa and the accession number is Q1NZ37.

Influenza A H3N2 (A Hong Kong 1 1968) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is Q91MA7.

Influenza A H2N2 (A Canada 720 2005) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59 kDa and the accession number is Q4ZH98.

Influenza A H3N2 (A Victoria 208 2009) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa.

Influenza A H1N1 (A California 07 2009) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59 kDa and the accession number is C3W5X2.

Influenza A H1N1 (A California 04 2009) Neuraminidase NA is expressed in HEK293 mammalian cells. The predicted molecular weight is 47.8 kDa and the accession number is C3W5S3.

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1 XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

Influenza A H3N2 (strain A X-31) Polymerase acidic Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.6 kDa and the accession number is Q9IQ47.

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.

Binds and inhibits the conjugation of the ubiquitin-like G1P2 ISG15 protein to its target proteins. Since G1P2 ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2 PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2 PKR. Also binds poly(A) and U6 snRNA.

Influenza B (strain B Lee 1940) Nucleoprotein NP Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 63.8 kDa and the accession number is P04665.

Influenza A H3N2 Neuraminidase NA Protein (E119V) is expressed in HEK293 mammalian cells. The accession number is C0LU95.

Influenza A H3N2 Neuraminidase NA Protein is expressed in HEK293 mammalian cells. The accession number is C0LU95.

Influenza A H5N8 (A broiler duck Korea Buan2 2014) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is W8NQ99.

Influenza B (B Utah 02 2012) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is K0BY85.

Influenza B (B PHUKET 3073 2013) Hemagglutinin HA0 Protein is expressed in Baculovirus insect cells. The predicted molecular weight is 61.7 kDa.

Influenza A H5N2 (A chicken Iowa 04-20 2015) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is A0A0F7GBN6.

Influenza A H3N2 (A Philippines 472 2002) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is A0A097PF18.

Influenza A H5N8 (A duck Zhejiang W24 2013) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is A0A023JQ41.

Influenza A H3N2 (A Nanchang 933 1995) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is A0A097PF06.

Influenza A H3N2 (A Hanoi EL201 2009) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.3 kDa and the accession number is A0A097PF44.

Influenza A H3N2 (A Guangdong-Luohu 1256 2009) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.2 kDa and the accession number is I6T542.

Influenza A H1N1 (A Bel 1942) Hemagglutinin HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is Q289C8.

Influenza A H5N8 (A breeder duck Korea Gochang1 2014) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is W8P1W5.

Influenza A H3N2 (A Missouri 09 2014) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.2 kDa.

Influenza A H10N7 (A blue-winged teal Louisiana Sg-00073 2007) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58 kDa and the accession number is D7EET9.

Influenza A H3N2 (A Perth 16 2009) Hemagglutinin HA-specific B cell probe Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58 kDa and the accession number is C6KNH7.

Influenza A H1N3 (A duck NZL 160 1976) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58.9 kDa and the accession number is Q20PD6.

Influenza A H5N6 (A duck Jiangxi 95 2014) Hemagglutinin HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.2 kDa.

Influenza A H1N1 (A Puerto Rico 8 1934) Neuraminidase NA Protein is expressed in HEK293 mammalian cells. The predicted molecular weight is 50.1 kDa and the accession number is P03468.2.