Colistin (Polymyxin E), a polypeptide antibiotic with oral activity, exhibits strong efficacy against a range of Gram-negative rod-shaped bacteria, such as multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. However, its use is associated with nephrotoxicity. It is primarily utilized in researching infections caused by Gram-negative bacilli [1] [2].