Fenofibric acid (FNF acid) is the active form of fenofibrate, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity.

PPARα:22.4 µM(EC50), PPARδ:1.06 µM(EC50), PPARγ:1.47 µM(EC50), COX-2:48 nM

纤维酸是纤维酸药物的有效形式，也是过氧化物酶体增殖剂激活受体-α（PPARα）的激活剂，已知具有提高高密度脂蛋白（HDL）的效果。纤维酸通过增强脂肪酸的分解作用，相应降低血浆脂质水平，主要是甘油三酯（TG）。Fenofibric acid 增加ABCA1的表达和apoA-I介导的HDL产生。ABCA1表达的增强通过增加ABCA1基因的转录而产生，这一过程依赖于LXR[1]。

Fenofibric acid 降低OIR小鼠体内循环EPC（内皮祖细胞）的异常增加。Fenofibric acid对OIR模型中EPC动员的抑制作用依赖于PPARα。Fenofibric acid 以PPARα依赖的方式抑制低氧诱导的视网膜EPC增加Fenofibric acid 减少循环中CXCR4阳性EPC的数量，下调血清SDF-1水平，并抑制视网膜中HIF-1a与SDF-1的过表达[1]。

PPAR activators fenofibric acid is dissolved in DMSO and added to the culture medium containing 0.2% BSA. RAW264 cells are washed with PBS and cultured an additional 48 hours in the presence of fenofibric acid in DMEM/F-12(1:1) medium containing 2% TCM and 0.2% BSA. During the last 24 hours of the drug treatment, 300 mol/L of dibutyryl cAMP and apoA-I (10 μg/mL) are added to the medium. THP-1 cells are also treated with the compound and apoA-I in 0.2% BSA-RPMI 1640 medium and 0.1% BSA-MEM. Cholesterol and choline-phospholipid released into the medium by apoA-I are determined enzymatically. Adherent cells are dissolved in 0.1 N NaOH for protein determination by bicinchoninic acid protein assay system. (Only for Reference)