NXT629

Name: NXT629
Brand: TargetMol
SKU: T12278
Price: 247 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T12278Cas号 1454925-59-7

NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).

为众多的药物研发团队赋能，

让新药发现更简单！

纯度: 无数据

产品编号 T12278Cas号 1454925-59-7

NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
靶点活性	PPARα (human):77 nM, PPARδ (human):6 μM, ERβ:15.2 μM, PPARγ (human):15 μM, GR:32.5 μM
体外活性	NXT629 is a potent and selective antagonist of PPAR-α(human PPARα,IC50 of 77 nM), shows high selectivity over other nuclear hormone receptor, [2].
体内活性	NXT629 has poor oral bioavailability in mice and rats.?NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice.?NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis.?NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung[2].

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 125 mg/mL (204.99 mM), Sonication is recommended.

溶液配制表

DMSO