NXT629

Name: NXT629
Brand: TargetMol
SKU: T12278
Price: 639 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T12278Cas号 1454925-59-7

NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).

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产品编号 T12278Cas号 1454925-59-7

NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).

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产品介绍

生物活性

产品描述	NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
靶点活性	PPARγ (human):15 μM, PPARδ (human):6 μM, GR:32.5 μM, ERβ:15.2 μM, PPARα (human):77 nM
体外活性	NXT629 is a potent and selective antagonist of PPAR-α(human PPARα,IC50 of 77 nM), shows high selectivity over other nuclear hormone receptor, [2].
体内活性	NXT629 has poor oral bioavailability in mice and rats.?NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice.?NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis.?NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung[2].

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 125 mg/mL (204.99 mM), Sonication is recommended.

溶液配制表