10000+
704
2
118
76
Cat. No. | Product Name | ||
---|---|---|---|
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L4020 | NO PAINS 化合物库 | 9384 compounds | |
TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物,可用于新药研发,信号通路研究,老药新用等研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9215 |
ELOVL6-IN-2
|
Others | Others |
ELOVL6-IN-2 是具有口服活性的ELOVL6选择性抑制。它抑制小鼠ELOVL6活性的IC50值为 34 nM。 | |||
T35862 |
Cucurbit[8]uril
|
Others | Others |
Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications. | |||
T9164 |
BMS-986242
BMS986242 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂,可用于研究癌症。 | |||
T9223 |
RO-0335
|
Reverse Transcriptase | Microbiology/Virology |
RO-0335 是新高效二苯醚非核苷逆转录酶抑制剂。它 (IC50= 1.1 nM) 可以抑制Wt HIV-1病毒,对 92% 的 NNRTI 耐药临床分离株具有保留活性 (IC50<100 nM)。 | |||
T9194 |
UMB298
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
UMB298 是一种有效的选择性 CBP/P300 溴结构域抑制剂,抑制 BRD4,IC50 为 5193nM。 | |||
T10525 |
SCD1 inhibitor-4
|
Dehydrogenase; Stearoyl-CoA Desaturase (SCD) | Metabolism |
SCD1 inhibitor-4 是一种具有口服活性的 stearoylCoA desaturase-1 抑制剂,可用于研究糖尿病。 | |||
T9214 |
ELOVL6-IN-1
|
Others | Others |
ELOVL6-IN-1 是一种选择性 ELOVL6抑制剂,口服具有活性。它对丙二酰辅酶 a (Ki:994 nM) 和对棕榈酰辅酶 a 具有非竞争性抑制 ELOVL6 作用。它能够剂量依赖性的一种小鼠 ELOVL6(IC50:0.350 μM)。 | |||
T25492 |
Hepln-13
Hepln 13,Hepln13 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Hepln-13 是具有口服活性的Hepsin 抑制剂(IC50:0.33 µM)。它可用于研究转移性前列腺癌。 | |||
T28804 |
Slingshot inhibitor D3
JHN76359 |
Others | Others |
Slingshot inhibitor D3 (JHN76359) 是具有选择性、竞争性、可逆性的Slingshot 抑制剂。它对Slingshot 1和Slingshot 2具有相似的抑制活性。它对Slingshot 1 的IC50为 3 μM;对Slingshot 2 的Ki 为 3.9 μM。 | |||
T9202 |
DDO-5936
|
HSP | Cytoskeletal Signaling; Metabolism |
DDO-5936 是一种特异性Hsp90-Cdc37 PPI 抑制剂,可研究大肠癌。 | |||
T36670 |
JNJ-67856633
|
MALT | Immunology/Inflammation |
JNJ-67856633 是口服有效的、选择性的、变构性的 MALT1 protease 抑制剂。在某些情况下,JNJ-67856633可以导致肿瘤停滞。 | |||
T26324 |
VU0071063
VU 0071063,VU-0071063 |
Potassium Channel | Membrane transporter/Ion channel |
VU0071063 是特异的Kir6.2/SUR1开启剂 (EC50=7.44 μM),可用于研究Kir6.2 /SUR1在大脑和胰腺中的表达。它可以诱导 β 细胞膜电位的超极化从而抑制胰岛素的分泌。 | |||
T3691 |
(Rac)-SAR131675
SAR131675 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
(Rac)-SAR131675 是一种有效的、选择性的VEGFR3抑制剂,其IC50=23 nM。 | |||
T4697 |
ABBV-744
ABBV744 |
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
ABBV-744 是一种 BDII 选择性 BET 溴结构域抑制剂,可抑制 BRD2/3/4。 它可研究炎症性疾病、癌症和艾滋病。 | |||
T9541 |
CTB
Cholera Toxin B subunit |
Epigenetic Reader Domain | Chromatin/Epigenetic |
CTB (Cholera Toxin B subunit) 是一种 p300 组蛋白乙酰转移酶的激活剂,可诱导 MCF-7 细胞凋亡。 | |||
T9276 |
SBC-115337
|
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-115337 是苯并呋喃化合物,也是 PCSK9抑制剂 (IC50:0.5 μM) 。 | |||
T2024 |
A-803467
A 803467,A803467 |
Sodium Channel | Membrane transporter/Ion channel |
A-803467 是有效的、选择性的河豚毒素不敏感型Nav1.8 钠通道阻断剂 。它在炎症性疼痛和神经性疼痛模型中有缓解疼痛作用。它通过与 ATP-binding cassette subfamily G member 2 (ABCG2) 转运蛋白的相互作用,增强了传统抗癌物的化疗敏感性。 | |||
T15032 |
CYM50308
|
S1P Receptor; LPL Receptor | GPCR/G Protein |
CYM50308 是选择性和高亲和力的鞘氨醇-1-磷酸受体 4 激动剂,EC50为 56 nM。它对 S1P4-R 的选择性比 S1P5-R 高 37 倍。 | |||
T6977 |
SB-366791
SB366791 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
SB366791 是一种有效的 vanilloid receptor (VR1/TRPV1)选择性拮抗剂 (IC50=5.7 nM)。SB-366791 在炎症方面有研究价值。 | |||
T35317 |
Zopolrestat
CP 73850,CP73850,CP-73850,唑泊司他,Zopolrestatum |
Reductase | Endocrinology/Hormones; Metabolism |
Zopolrestat (CP 73850) 是口服有效的醛糖还原酶抑制剂,IC50为3.1 nM。Zopolrestat (CP 73850) 在糖尿病并发症方面有研究的价值。 | |||
T6052 |
GW 441756
|
Apoptosis; Raf; Trk receptor; CDK | Apoptosis; Cell Cycle/Checkpoint; MAPK; Tyrosine Kinase/Adaptors |
GW 441756 是一种高特异性神经生长因子受体酪氨酸激酶 a 抑制剂 ,IC50值为 2 nM,可消除 BmK NSPK 诱导神经突生长。 | |||
T9167 |
PF-9363
CTX-3648 |
Histone Acetyltransferase | Chromatin/Epigenetic |
PF-9363 (CTX-3648) 是一种有效且高选择性的 KAT6A/KAT6B 抑制剂,可用于癌症研究。 | |||
T22282 |
Brr2-IN-3
Brr2 Inhibitor 9,Brr2 Inhibitor C9 |
Others | Others |
Brr2-IN-3 (Brr2 Inhibitor C9) 是选择性 Brr2解旋酶变构抑制剂。它呈剂量依赖性地抑制解旋酶(IC50:1.3 μM)。 | |||
T23524 |
W-84 dibromide
HDMPPA |
AChR | Neuroscience |
W-84 dibromide (HDMPPA) 是 M2胆碱受体的强变构调节剂,是一种非竞争性毒蕈碱乙酰胆碱受体拮抗剂,具有变构效应。它联合阿托品时,可有效地防止有机磷中毒。它阻碍 [3H]N-甲基东莨菪碱解离,能稳定胆碱能拮抗剂-受体复合物。 | |||
T6476 |
Dofetilide
UK 68789,UK-68798,Tikosyn,多非利特 |
Potassium Channel | Membrane transporter/Ion channel |
Dofetilide (UK 68789) 是一种具有口服活性、有效的且特异性的IKr 阻滞剂,作为 III 类抗心律失常药物。Dofetilide 可用于心血管疾病研究。 | |||
T5159 |
Olodaterol hydrochloride
BI-1744 HCl,盐酸奥达特罗,BI 1744 hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Olodaterol hydrochloride (BI-1744 HCl) 是一种长效的、选择性 β2-adrenoceptor(β2-AR) 激动剂 (EC50=0.1 nM;pKi= 9.14 for human β2-adrenoceptor),可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化的研究。 | |||
T9199 |
GLPG2938
1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea |
S1P Receptor; LPL Receptor | GPCR/G Protein |
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) 是一种选择性 S1P2拮抗剂,可用于特发性肺纤维化的研究。 | |||
T3457 |
Olodaterol
BI1744,Striverdi Respimat |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Olodaterol 是一种长效的、选择性 β2-adrenoceptor(β2-AR) 激动剂 (EC50=0.1 nM;pKi= 9.14 for human β2-adrenoceptor),可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化的研究。 | |||
T6804 |
Chetomin
Chaetomin,NSC289491,BRN0077366 |
Apoptosis; HSP; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism |
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。 | |||
T76505 |
Bradykinin potentiator B
|
||
Bradykinin potentiator B 是 Agkistrodon halys blomhoffi 的毒液。Bradykinin potentiator B 是一种有效的 ACE 抑制剂。Bradykinin potentiator B 抑制缓激肽抑制肽酶的活性。 | |||
T76507 |
Bradykinin potentiator C
|
||
Bradykinin potentiator C是一种有效的血管紧张素转化酶(ACE)抑制剂,对兔肺ACE的IC50值为7.1 μM,被认为是功能肽原型。 | |||
T63003 |
NMDA receptor potentiator-1
|
Others | Others |
NMDA receptor potentiator-1 (Compound 1368) 是一种亚基选择性的 NMDA receptor 增强剂。NMDA receptor potentiator-1 对 NR2C 和 NR2D 表达的 IC50 值分别为 4 μM 和 5 μM。 | |||
T25173 |
Bradykinin potentiator-5
BPP-5a\,BPP 5a\,BPP5a\ |
Others | Others |
Bradykinin potentiator-5 is a peptide inflammatory mediator, causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall. | |||
T22566 | Aminopotentidine | Others | Others |
H2 antagonist | |||
T28276 |
OV-potentiator-28
OV potentiator 28 |
Others | Others |
OV-potentiator-28 is a potentiator of cancer virotherapy. OV-potentiator-28 significantly enhances virus replication-associated luciferase expression, specifically in tumors. | |||
T10550 |
Bisindolylmaleimide X hydrochloride
BIM-X hydrochloride,Ro31-8425 hydrochloride |
CDK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling |
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM). | |||
T29023 |
Tubastatin
|
Others | Others |
Tubastatin TFA salt is a highly potent, selective inhibitor of HDAC6. | |||
T15614 |
JJKK 048
|
Lipase | Metabolism |
JJKK 048 是一种有效的特异性 MAGL 抑制剂。 | |||
T40146 |
Sec61-IN-1
Sec61-IN-1 |
Others | Others |
Sec61-IN-1是一种有效的Sec61抑制剂。 | |||
T16526 |
Phorbol 12,13-dibutyrate
PDBu,Phorbol dibutyrate |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter. | |||
T60101 |
PLN-1474
PLN1474 |
Integrin | Cytoskeletal Signaling |
PLN-1474 是一种有效的 αVβ1 抑制剂,IC50 < 50 nM。 | |||
T10746 |
CDK9-IN-8
|
CDK | Cell Cycle/Checkpoint |
CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM). | |||
T24488 |
MLS000545091
MLS-000545091,MLS 000545091 |
Others | Others |
MLS000545091 is a potent and selective human epithelial 15-lipoxygenase-2 mixed-type inhibitor. | |||
T12102 |
Mps1-IN-1
|
Others | Others |
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) | |||
T12030 |
MG 1
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
MG 1是一种有效的 α1肾上腺素能受体拮抗剂。 | |||
T28501 |
Ragaglitazar
NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Ragaglitazar(NNC-61-0029) 是一种有效的 PPARα和 PPARγ双重激动剂,在动物模型中显示出有效的降脂和胰岛素增敏作用。Ragaglitazar 可用于研究 2 型糖尿病。 | |||
T11943 |
MAPK13-IN-1
|
p38 MAPK | MAPK |
MAPK13-IN-1 是一种有效的 MAPK13 (p38δ) 抑制剂(IC50:620 nM)。 | |||
T5013 |
Brequinar
Bipenquinate,NSC 368390,DUP785,布喹那 |
Virus Protease; Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brequinar (NSC-368390) 是二氢乳清酸脱氢酶的一种强效抑制剂,对广谱病毒具有强效活性。 | |||
T36491 |
POMHEX
|
Glucokinase | Metabolism |
Pomhex 是一种具有抗癌活性的细胞渗透性强效烯醇化酶抑制剂,可用于癌症致死率的研究。Pomhex是一种外消旋混合物,是一种强效且具有选择性的ENO2抑制剂。 | |||
T29930 |
AM-1235
AM 1235,AM1235 |
Cannabinoid Receptor | GPCR/G Protein |
AM-1235 是一种有效的选择性大麻素受体 CB1 激动剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21351 |
Maytansine
NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新 |
Microtubule Associated; Antibiotic | Cytoskeletal Signaling; Microbiology/Virology |
Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物,可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。 | |||
TN6774 |
Emodin 6-O-β-D-glucoside
大黄素-6-O-β-D-葡萄糖苷,Glucoemodin |
Others | Others |
Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性,可用于研究动脉粥样硬化及糖尿病并发症。 | |||
T81418 |
Potentillanoside A
|
||
Potentillanoside A 是一种具有肝脏保护功能的天然化合物。 | |||
T22644 |
C2 Ceramide
Ceramide |
Others | Others |
A potent modulator of cell proliferation and differentiation. | |||
TN1160 |
1,2,3,6-Tetragalloylglucose
1,2,3,6-Tetra-O-galloyl-β-D-glucose,1,2,3,6-四-O-没食子酰-Β-D-葡萄糖,TeGG |
LDL; UGT | Metabolism |
1,2,3,6-Tetragalloylglucose (TeGG) 是 UDP-葡萄糖醛酸转移酶 1 家族成员,是多肽A1 的抑制剂(Ki:1.68 μM)。 | |||
T2937 |
4'-Demethylepipodophyllotoxin
4'-DMEP,4-Demethylepipodophyllotoxin,4'-脱甲基表鬼臼毒素,4'-去甲基表鬼臼毒素,DMEP,4'-O-demethylepipodophyllotoxin |
Microtubule Associated | Cytoskeletal Signaling |
4'-Demethylepipodophyllotoxin (DMEP) 是一种有效的微管组装抑制剂。 | |||
TN1469 |
Cassiaside B
|
Others; Antibacterial | Microbiology/Virology; Others |
Cassiaside B 是一种具有强效抗菌活性的天然产物。 | |||
T7972 |
Gallic aldehyde
3,4,5-三羟基苯甲醛,五倍子醛 |
HSV | Microbiology/Virology |
Gallic aldehyde 对 HSV-1 显示出有效的抗病毒活性。 | |||
T7981 |
2-Fluoroadenosine
|
Others | Others |
2-Fluoroadenosine 是淋巴细胞介导的细胞溶解的有效抑制剂。 | |||
T8273 |
4,6-Dioxoheptanoic acid
Succinylacetone,4,6-二氧代庚酸 |
Others; Endogenous Metabolite | Metabolism; Others |
4,6-Dioxoheptanoic acid (Succinylacetone) 是血红素生物合成的有效抑制剂。 | |||
T2266 |
SantacruzaMate A
CAY-10683 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SantacruzaMate A (CAY-10683) 是一种高效选择性的HDAC2抑制剂,IC50为 119 pM。 | |||
T8035 |
3'-Methoxyflavonol
|
NMU2R | Neuroscience |
3'-Methoxyflavonol 是一种神经介肽 U 2 受体的选择性激动剂。 | |||
TN1325 |
(2S)-6-Prenylnaringenin
(2S)-6-异戊烯基柚皮素,6-异戊二烯基柚皮素,6-Prenylnaringenin,6-PN |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) 是强效植物雌激素 8-prenylnaringenin 的异构体,是前脑中最有效的化合物,在 α+β 结合位点上起GABAA 正变构调节剂的作用。 | |||
TN1626 |
Eugenin
|
Others | Others |
Eugenin 是一种色酮,分离自滨海前胡,能够抗血小板聚集。 | |||
TN4171 |
Grossamide
|
NO Synthase | Immunology/Inflammation |
Grossamide (GSE) 是一种来自虎杖的木脂酰胺。Grossamide 具有抗炎症活性,可通过上调精氨酸酶和下调诱导型一氧化氮合酶来抑制精氨酸产生一氧化氮(NO),抑制NO对OXPHOS的抑制作用。 | |||
T3364 |
Veratramine
NSC17821,黎芦碱,NSC23880,藜芦胺 |
Sodium Channel | Membrane transporter/Ion channel |
Veratramine (NSC-23880) 是一种信号转导抑制剂,可作用于肿瘤。 | |||
TN1455 |
Bryodulcosigenin
|
Immunology/Inflammation related | Immunology/Inflammation |
Bryodulcosigenin 是一种 Bryoniadioica 根的提取物,具有抗炎活性。 | |||
TQ0188 |
Miquelianin
槲皮素-3-O-葡萄糖醛酸苷,Quercetin 3-glucuronide,Quercetin 3-O-glucuronide |
stilbene oxidase; Endogenous Metabolite | Metabolism |
Miquelianin (Quercetin 3-glucuronide) 是槲皮素的代谢产物,属于类黄酮化合物。 | |||
TL0015 |
Pyromeconic acid
3-羟基-4氢-吡喃-4-酮,3-hydroxy-4H-pyran-4-one |
Anti-infection | Microbiology/Virology |
Pyromeconic acid (3-hydroxy-4H-pyran-4-one) 及其衍生物是核酸内切酶的有效抑制剂 | |||
TN4871 |
Pyrolin
|
Anti-infection | Microbiology/Virology |
Pyrolin 具有很强的抗真菌活性,并对 M.fructicola 的超微结构产生强大的影响。 | |||
TQ0172 |
2''-O-Rhamnosylicariside II
|
Others | Others |
2''-O-Rhamnosylicariside II 是天然来源的黄酮类糖苷化合物,可能对改善绝经后骨质疏松有益处。 | |||
TQ0170 |
Desacetylcinobufagin
Deacetylcinobufagin,去乙酰华蟾蜍精 |
Others | Others |
Desacetylcinobufagin (Deacetylcinobufagin) 是一种天然化合物,可用于微生物转化。 | |||
T3718 |
Santonin
驱蛔蒿,α-santonin,alpha-Santonin,山道年,Semenen |
Others; Parasite | Microbiology/Virology; Others |
Santonin (alpha-Santonin) 是Artemisia cina 的活性成分,可用于研究蠕虫感染。它是一种有效的抗寄生虫剂。 | |||
T8433 |
HQNO
|
Mitochondrial Metabolism | Metabolism |
HQNO 是一种电子传递链抑制剂,对 complex III 的Kd 值为 64 nM,由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。 | |||
T3S1447 |
Arteannuin B
|
SARS-CoV; Ferroptosis | Apoptosis; Microbiology/Virology |
Arteannuin B 与青蒿素共同存在,有强效抗疟活性,具有抗 SARS-CoV-2 的活性,EC50为 10.28 μM。 | |||
T2736 |
Sodium Demethylcantharidate
Sodium norcantharidin,去甲斑蝥酸钠 |
Others; Endogenous Metabolite | Metabolism; Others |
Sodium Demethylcantharidate (Sodium norcantharidin) 是内源性代谢产物的一种。 | |||
T31866 |
FR901464
FR 901464,FR-901464,WB 2663B |
Others | Others |
FR901464 (WB 2663B)是具有强细胞毒性的天然产物,共享一个含胺的四氢吡喃环。 | |||
T4614 |
Ellipticine hydrochloride
Ellipticine HCl,NSC 71795 (hydrochloride),玫瑰树碱盐酸盐 |
Topoisomerase | DNA Damage/DNA Repair |
Ellipticine hydrochloride (NSC-71795 (hydrochloride)) 是一种有效的抗肿瘤剂,抑制 DNA 拓扑异构酶 II 的活性。 | |||
T3888 |
Scopolin
Murrayin,东莨菪甙,Scopoloside,东莨菪苷 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Scopolin (Scopoloside) 是从拟南芥根中分离出来的香豆素,可通过激活SIRT1介导的信号级联反应减轻了肝脂肪变性。 | |||
T5S2204 |
Sibiricose A6
西伯利亚远志糖A6 |
Antioxidant | oxidation-reduction |
Sibiricose A6 是一种寡糖酯,分离自Polygalae Radix,具有抗氧化作用。 | |||
TMS1743 |
Salvigenin
|
MAO; Autophagy; ROS Kinase | Autophagy; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors |
Salvigenin 是从鼠尾草中发现的一种多酚类天然产物,具有神经保护、抗肿瘤、免疫调节和细胞毒作用。 | |||
TN1829 |
Kakkalide
|
Dehydrogenase | Metabolism |
Kakkalide 是提取自葛根花中的一种异黄酮。它可以抑制活性氧相关炎症,并改善内皮细胞胰岛素抵抗作用。 | |||
T3750 |
4-Hydroxyacetophenone
对羟基苯乙酮,4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone |
HBV; Xanthine Oxidase | Metabolism; Microbiology/Virology |
4-Hydroxyacetophenone (4-Acetylphenol) 是蒿属植物和木香属植物中的一种黄嘌呤氧化酶抑制剂,具有保肝促胆、抗乙型肝炎病毒和抗炎作用。 | |||
TQ0217 |
Gomisin G
戈米辛G,戈米辛 G |
P450; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Gomisin G 是一种有抗HIV 活性的天然产物。 | |||
TN1899 |
Lycoramine
|
AChE | Neuroscience |
Lycoramine 是一种加兰他敏的二氢衍生物,从Lycoris radiate 中分离得到,是一种乙酰胆碱酯酶抑制剂。 | |||
T7344 |
SDMA
NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine,对称N,N-二甲基精氨酸 |
Endogenous Metabolite | Metabolism |
SDMA (Symmetric dimethylarginine) 是一氧化氮 (NO) 合酶的内源性抑制剂。 | |||
T5A2455 |
Arenobufagin
沙蟾毒精,沙蟾毒经 |
Others | Others |
Arenobufagin 是一种蟾蜍甾烯,从蟾蜍毒液中提取得到,具有抗癌活性。 | |||
T5743 |
Gymnemagenin
|
Liver X Receptor | Metabolism |
Gymnemagenin 是一种分离自G. sylvestre 的三萜。 它具有抗病毒作用,对糖尿病和肥胖症具有潜在的研究价值。 | |||
T3S1957 |
9-amino-CPT
9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin |
Topoisomerase | DNA Damage/DNA Repair |
9-amino-CPT (Aminocamptothecin) 是一种拓扑异构酶I 的抑制剂,具有抗肿瘤活性。 | |||
TN7051 |
2,4-Dihydroxybenzaldehyde
2,4-二羟基苯甲醛,4-Formylresorcinol,beta-Resorcylaldehyde,4-Hydroxysalicylaldehyde |
Endogenous Metabolite | Metabolism |
2,4-Dihydroxybenzaldehyde (4-Formylresorcinol) 是内源性代谢产物的一种。 | |||
T21820 |
Resistomycin
Geliomycin,Heliomycin |
Antibiotic | Microbiology/Virology |
Resistomycin(Geliomycin),一种五环多酮类抗生素,通过触发凋亡展现出强大的抗癌特性。 | |||
T1648 |
α-Vitamin E
天然维生素E,Dexrabeprazole Sodium,Vitamin E,Alpha-Tocopherol,D-α-Tocopherol,5,7,8-Trimethyltocol,D-α-生育酚,(+)-alpha-Tocopherol |
Others; Ferroptosis; Influenza Virus; Reactive Oxygen Species; Endogenous Metabolite; Antibacterial; PKC; GST | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Others; oxidation-reduction |
α-Vitamin E (Dexrabeprazole Sodium) 是一种天然存在的维生素 E,也是抗氧化剂。 | |||
T2S0765 |
Epibetulinic acid
|
NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用,IC50分别为 0.7 和 0.6 μM,具有抗炎活性。 | |||
T3S2152 |
23-Hydroxybetulinic acid
Anemosapogenin,23-羟基白桦酸 |
Others | Others |
23-Hydroxybetulinic acid (Anemosapogenin) 是一种具有抗癌作用的生物化合物。 | |||
T22857 |
Illudin S
|
Apoptosis; DNA Alkylator/Crosslinker; Antifungal | Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology |
Illudin S (ILS)是一种真菌倍半萜次生代谢物,具有很强的遗传毒性和细胞毒性 | |||
T4S1521 |
1,4-Dicaffeoylquinic acid
1,4-二咖啡酰奎宁酸,洋蓟素 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
1,4-Dicaffeoylquinic acid 是一种苯丙素类物质,从苍耳子中获得,可以减少 LPS 诱导的 TNF-α 的生成,具有抗炎活性。 | |||
T12536 |
Pregnenolone monosulfate
3β-Hydroxy-5-pregnen-20-one monosulfate |
NMDAR | Neuroscience |
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) 是一种强效神经类固醇,可正向调节 NMDA 记录,可用于研究神经分裂和抑郁症。 | |||
T2S1434 |
Bergaptol
5-Hydroxyfuranocoumarin,4-Hydroxybergapten,5-羟基-6,7-呋喃并香豆素,5-Hydroxypsoralen |
P450 | Metabolism |
Bergaptol (4-Hydroxybergapten) 是CYP3A4酶脱苄基作用的抑制剂(IC50:24.92 uM),具有抗癌、抗增殖作用。 | |||
T12095 |
Monomethyl fumarate
|
GPR; Drug Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism |
Monomethyl fumarate 是 Dimethyl fumarate 的活性代谢产物。Monomethyl fumarate 是一种 GPR109A 激动剂。Monomethyl fumarate 是一种 GPR109A 激动剂具有用于多种神经保护途径和其他视网膜疾病模型的潜力。 | |||
T3056 |
Bavachinin
补骨脂二氢黄酮加醚,补骨脂二氢黄酮甲醚,Bavachinin A,7-O-Methylbavachin |
PPAR | DNA Damage/DNA Repair; Metabolism |
Bavachinin (Bavachinin A) 是一种具有抗炎症和抗血管生成作用的天然化合物。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00823 |
VEGF165 Protein, Human, Recombinant (His & Avi)
血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGFMGC70609,VPF,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPJ-00779 |
TNF alpha Protein, Rabbit, Recombinant
TNF-a,Tumor Necrosis Factor,TNF-α,TNF α,Cachectin,肿瘤坏死因子,Tum... |
Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ... | |||
TMPJ-01464 |
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TCGF,Aldesleukin,T-Cell Growth Factor,IL-2,Interleukin-2,IL2 |
Human | HEK293 Cells |
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages... | |||
TMPJ-00735 |
PDGF-BB Protein, Human, Recombinant
PDGF-BB,血小板源生长因子,PDGFBB |
Human | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In a... | |||
TMPJ-00603 |
TL1A/TNFSF15 Protein, Mouse, Recombinant
TNFSF15,Tumor Necrosis Factor Ligand Superfamily Member 15,V... |
Mouse | E. coli |
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial ... | |||
TMPJ-00562 |
PDGF-BB Protein, Mouse, Recombinant (His)
PDGFBB,PDGF-BB,血小板源生长因子 |
Mouse | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor,it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival... | |||
TMPJ-00864 |
VEGF165 Protein, Human, Recombinant
Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul... | |||
TMPJ-01469 |
NGF Protein, Human, Recombinant (E. colli)
NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Nerve Growt... |
Mouse | E. coli |
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo... | |||
TMPJ-00059 |
IL-7 Protein, Human, Recombinant (His)
Interleukin-7,IL7,白细胞介素,IL-7,白介素 |
Human | HEK293 Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe... | |||
TMPJ-01172 |
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CTLA-8,Cytotoxic T-Lympho... |
Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... | |||
TMPY-02115 |
R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
CRISTIN1,THSD2,R-spondin 3,PWTSR |
Human | HEK293 Cells |
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s... | |||
TMPY-02869 |
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12 |
Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... | |||
TMPK-00825 |
VEGF121 Protein, Human, Recombinant (His & Avi)
VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609,RP1-261G23.1,M... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9. | |||
TMPK-00826 |
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MVCD1,VEGF,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9. | |||
TMPK-00822 |
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGFMGC70609,VPF,VAS,MVCD1,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPH-02046 |
Ribonuclease 7 Protein, Human, Recombinant (His)
RNASE7,Skin-derived antimicrobial protein 2,Ribonuclease 7 |
Human | E. coli |
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. Ribonuclease 7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted... | |||
TMPH-02545 |
DEFB6 Protein, Mouse, Recombinant (His & KSI)
Defb6,Beta-defensin 6,Defensin, beta 6,mBD-6,BD-6 |
Mouse | E. coli |
Has potent antibacterial activity against E.coli (ATCC 25922). DEFB6 Protein, Mouse, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.8 kDa and the accession number is Q91VD6. | |||
TMPH-00229 |
Cathelicidin-4 Protein, Bovine, Recombinant (His & SUMO)
Cathelicidin-4,Indolicidin,CATHL4 |
Bovine | E. coli |
Potent microbicidal activity; active against S.aureus and E.coli. Cathelicidin-4 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 17.9 kDa and the accession number is P33046. | |||
TMPH-01026 |
CAMK2N1 Protein, Human, Recombinant (His & Trx)
Calcium/calmodulin-dependent protein kinase II inhibitor 1,C... |
Human | E. coli |
Potent and specific inhibitor of CaM-kinase II (CAMK2). CAMK2N1 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-Trx tag. The predicted molecular weight is 25.6 kDa and the accession number is Q7Z7J9. | |||
TMPH-02732 |
IFNAR2 Protein, Mouse, Recombinant (His)
Ifnar2,Type I interferon receptor 2,Interferon alpha/beta re... |
Mouse | P. pastoris (Yeast) |
Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; May be potent inhibitors of type I IFN receptor activity.; May be potent inhibitors of type I IFN receptor activity. IFNAR2 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.8 ... | |||
TMPH-02514 |
APOA4 Protein, Mouse, Recombinant (His)
Apolipoprotein A4,Apolipoprotein A-IV,ApoA-IV,Apo-AIV,Apoa4 |
Mouse | P. pastoris (Yeast) |
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. | |||
TMPH-00061 |
Defensin-1 Protein, Apis mellifera carnica, Recombinant (His & KSI)
|
Apis mellifera carnica | E. coli |
Found in royal jelly and in hemolymph, potent antibacterial protein against Gram-positive bacteria at low concentration. Defensin-1 Protein, Apis mellifera carnica, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 20.9 kDa and the accession number is Q5J8R1. | |||
TMPH-00056 |
Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)
ATX II,Delta-AITX-Avd1c,Toxin II,Delta-actitoxin-Avd1c,Neuro... |
Anemonia sulcata | P. pastoris (Yeast) |
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured... | |||
TMPH-01414 |
GDF2 Protein, Human, Recombinant (His)
Growth/differentiation factor 2,Bone morphogenetic protein 9... |
Human | P. pastoris (Yeast) |
Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. GDF2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 16.3 kDa and the accession number is Q9UK05. | |||
TMPH-00063 |
Defensin-1 Protein, Apis mellifera, Recombinant (His)
|
Apis mellifera | E. coli |
Found in royal jelly and in hemolymph, potent antibacterial protein against Gram-positive bacteria at low concentration. Defensin-1 Protein, Apis mellifera, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 11.6 kDa and the accession number is P17722. | |||
TMPH-00230 |
Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO)
CATHL6,Antibacterial peptide BMAP-27,Myeloid antibacterial p... |
Bovine | E. coli |
Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 16.2 kDa and the accession number is P54228. | |||
TMPH-01302 |
HSD17B1 Protein, Human, Recombinant (His & Myc)
Placental 17-beta-hydroxysteroid dehydrogenase,Short chain d... |
Human | E. coli |
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH. HSD17B1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 42.3 kDa and the accession number is P14061. | |||
TMPH-03701 |
Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI)
Vespakinin-M,Bradykinin-related peptide |
Vespa mandarinia | E. coli |
Bradykinins are a potent but short-lived agent of arteriolar dilation and increased capillary permeability. May target bradykinin receptors (BDKRB). May cause hypotension. Vespakinin-M Protein, Vespa mandarinia, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 16.7 kDa and the accession number is Q7M3T3. | |||
TMPK-00618 |
FcRH5/FcRL5 Protein, Human, Recombinant (His)
FcR-like protein 5,CD307,BXMAS1,FcRH5,IFGP5,CD307e,FcRL5 |
Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971. | |||
TMPK-01477 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
HPAFP,FETA,Alpha-1-fetoprotein,AFPD,AFP,Alpha-feto,MHC,Alpha... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01484 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
HPAFP,FETA,AFP,AFPD,Alpha-1-fetoprotein,MHC,Alpha-fetoprotei... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-00619 |
FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
IFGP5,CD307,FCRH5MGC119593,FLJ00397,DKFZp667E2019,BXMAS1MGC1... |
Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971. | |||
TMPH-01076 |
CEMP1 Protein, Human, Recombinant (His)
Cementoblastoma-derived protein 1,Cementum protein 1,CEMP1,C... |
Human | P. pastoris (Yeast) |
May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum. Binds hydroxyapatite and may promote the biomineralization of the cementum. Also promotes cell proliferation. CEMP1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 28.0 kDa and the accession number is Q6PRD7. | |||
TMPK-01482 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
MHC,AFPD,Alpha-fetoprotein,FETA,Alpha-1-fetoprotein,AFP,HPAF... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01521 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi)
MHC,Alpha-feto,AFPD,Alpha-1-fetoprotein,Alpha-fetoprotein,FE... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01436 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Alpha-1-fetoprotein,FETA,MHC,Alpha-feto,AFPD,Alpha-fetoprote... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01478 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
AFP,FETA,Alpha-feto,HPAFP,Alpha-1-fetoprotein,MHC,Alpha-feto... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPH-03262 |
Cathepsin K Protein, Rat, Recombinant (His)
CTSO,CTSO2,Cathepsin O2,Cathepsin X,Cathepsin O,CTSK,Catheps... |
Rat | E. coli |
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | |||
TMPK-01483 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
AFPD,AFP,Alpha-fetoprotein,HPAFP,MHC,FETA,Alpha-1-fetoprotei... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01515 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
HPAFP,Alpha-fetoprotein,MHC,FETA,Alpha-feto,Alpha-1-fetoprot... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPH-02611 |
Langerin/CD207 Protein, Mouse, Recombinant (His)
C-type lectin domain family 4 member K,Langerin,Cd207 |
Mouse | E. coli |
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. | |||
TMPK-01145 |
FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated
CD307,FcRL5,FcR-like protein 5,FCRH5MGC119593,DKFZp667F216,B... |
Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 94.19 kDa and the accession number is Q96RD9-1. | |||
TMPH-03312 |
HGF Protein, Rat, Recombinant (GST)
Hepatopoietin-A,Hgf,Hepatocyte growth factor,Scatter factor |
Rat | E. coli |
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. HGF Protein, Rat, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 55.0 kDa and the accession number is P17945. | |||
TMPJ-00207 |
AKR1C2 Protein, Human, Recombinant
3-Alpha-HSD3,Chlordecone Reductase Homolog HAKRD,2-Diol Dehy... |
Human | E. coli |
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol). | |||
TMPH-00368 |
FGF-2 Protein, Chicken, Recombinant (His)
Heparin-binding growth factor 2,FGF2,Fibroblast growth facto... |
Chicken | P. pastoris (Yeast) |
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. FGF-2 Protein, Chicken, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P48800. | |||
TMPK-01519 |
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
MHC,FETA,AFP,Alpha-feto,AFPD,Alpha-1-fetoprotein,HPAFP,Alpha... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01520 |
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Tetramer Protein, Human, MHC (His & Avi)
Alpha-1-fetoprotein,AFP,HPAFP,FETA,AFPD,MHC,Alpha-fetoprotei... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01417 |
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Alpha-1-fetoprotein,HPAFP,AFPD,AFP,Alpha-feto,MHC,FETA,Alpha... |
Human | HEK293 Cells |
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response. | |||
TMPK-01039 |
FcRH5/FcRL5 Protein, Mouse, Recombinant (His)
CD307e,FcRL5,BXMAS1MGC119592,IFGP5,FcRH5,BXMAS1,CD307,DKFZp6... |
Mouse | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q68SN8-1. | |||
TMPH-01424 |
GUCA2B Protein, Human, Recombinant (His)
Guanylate cyclase activator 2B,GUCA2B |
Human | HEK293 Cells |
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26871 |
BMT-052
BMT052 |
||
BMT-052 is a potent and selective Pan-genotypic HCV NS5B Polymerase Inhibitor (EC50 = 7 nM). | |||
T12571 |
PSI-6206 13C,d3
Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3 |
Others | Others |
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor. | |||
T11675 |
Irbesartan-d4
厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4 |
Others | Others |
Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor. | |||
T27982 |
MBRI-001
MBRI 001,MBRI001. BPI-2358-d,plinabulin-d,NPI-2358-d |
||
MBRI-001 is a deuterium-substituted plinabulin derivative and a potent anti-cancer agent with better pharmacokinetic characteristics tand lower toxicity. | |||
T10231 |
Acetazolamide-d3
醋氮酰胺 D3 |
Others | Others |
Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor. | |||
T12292 |
Olaparib-d5
KU0059436 D5,AZD2281 D5,Olaparib D5 |
Others | Others |
Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP. | |||
T12222 |
Nifedipine-d6
硝苯地平 D6,Nifedipine D6,BAY-a-1040 D6 |
Others | Others |
Nifedipine D6 is deuterium labeled nifedipine which is a potent blocker of calcium channel. | |||
T12488 |
Pitavastatin D4
NK-104 D4 |
Others | Others |
Pitavastatin D4 is deuterium labeled Pitavastatin. Pitavastatin is a potent inhibitor of HMG-CoA reductase. | |||
T13076 |
Tamoxifen-d5
ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5 |
HSP | Cytoskeletal Signaling; Metabolism |
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity. | |||
T12648 |
(R)-VX-984
(R)-M9831 |
Others | Others |
(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK. | |||
T11250 |
Ezetimibe-d4
SCH 58235 D4 |
Others | Others |
Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation of Nrf2. | |||
T13121 |
Teneligliptin D8
MP-513 D8 |
Others | Others |
Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4. | |||
T11655 |
Indomethacin-D4
Indometacin-D4,吲哚美辛-D4 |
CDK | Cell Cycle/Checkpoint |
Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. | |||
T12691 |
Rapamycin-d3
AY-22989-d3,Sirolimus-d3 |
Others | Others |
Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells). | |||
T11152 |
Edaravone-d5
MCI-186 D5 |
Others | Others |
Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits. | |||
T12736 |
Rivaroxaban-d4
BAY 59-7939 D4 |
Factor Xa | Metabolism |
Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM). | |||
T12955 |
Sofosbuvir D6
PSI-7977 D6,GS-7977 D6 |
Others | Others |
Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. | |||
T13400 |
Ziprasidone D8
CP-88059 D8 |
Others | Others |
Ziprasidone D8 is deuterium labeled Ziprasidone, which is a antagonist of combined 5-HT (serotonin) and dopamine receptor and exhibits potent effects of antipsychotic activity. | |||
TMIH-0423 |
Penfluridol-d7
|
||
Penfluridol-d7 是 Penfluridol 的氘代化合物。Penfluridol 的 CAS 号为 26864-56-2。Penfluridol是一种高效的二苯类抗精神病药物。 | |||
TMIH-0595 |
Vericiguat-d3
|
||
Vericiguat-d3 是 Vericiguat 的氘代化合物。Vericiguat 的 CAS 号为 1350653-20-1。Vericiguat 是一种有效的口服鸟苷酸环化酶刺激剂。 | |||
T39441 |
L-Arginine-15N4 hydrochloride
L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride |
||
L-Arginine-15N4 ((S)-(+)-Arginine-15N4) hydrochloride, the 15N-labeled variant of L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as the nitrogen donor in the synthesis of nitric oxide. This potent vasodilator is crucial, especially during a sickle cell crisis where its levels are notably diminished. | |||
T11197 |
Enclomiphene D4 hydrochloride
(E)-Clomiphene D4 hydrochloride,Enclomifene D4 hydrochloride,trans-Clomiphene D4 hydrochloride |
Others | Others |
Enclomiphene D4 hydrochloride ((E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride) is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property.Enclomiphene D4 hydrochloride ((E)-Clomiphene D4 hydrochloride; trans-Clomiphene D4 hydrochloride; Enclomifene D4 hydrochloride) is a deuterium labeled Enclomiphene. | |||
TMIH-0206 |
Dydrogesterone-d6
|
||
Dydrogesterone-d6 是 Dydrogesterone 的氘代化合物。Dydrogesterone 的 CAS 号为 152-62-5。Dydrogesterone 是一种口服有效的孕激素,可作用于孕酮缺乏相关疾病。 | |||
T10118 |
3-O-Methyltolcapone D7
Ro 40-7591 D7 |
Transferase | Metabolism |
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P | |||
T62624 |
LpxA-IN-1
|
||
LpxA-IN-1 是一种新型的 UDP-N-乙酰氨基葡萄糖酰基转移酶 (LpxA)抑制剂(IC502 nM)。LpxA-IN-1 具有抑制 Pseudomonas aeruginosa(MIC 8 μg/mL)的活性。 | |||
TMIJ-0336 |
Imidafenacin-d10
|
||
Imidafenacin-d10 是 Imidafenacin 的氘代化合物。Imidafenacin 的 CAS 号为 170105-16-5。Imidafenacin 是一种有效的和选择性的M3受体抑制剂,Kb值为0.317nM。 | |||
TMIJ-0057 |
5α-Dihydrotestosterone-d4
|
||
5α-Dihydrotestosterone-d4 是 5α-Dihydrotestosterone 的氘代化合物。5α-Dihydrotestosterone 的 CAS 号为 521-18-6。Dihydrotestosterone(DHT) 是睾酮的强效雄激素代谢物。它是雄激素受体的激动剂。 | |||
TMIJ-0248 |
Stanolone-d4
|
||
Stanolone-d4 是 Stanolone 的氘代化合物。Stanolone 的 CAS 号为 521-18-6。Dihydrotestosterone(DHT) 是睾酮的强效雄激素代谢物。它是雄激素受体的激动剂。 | |||
TMID-0130 |
CORTISONE(2,2,4,6,6,9,12,12-d8)
|
||
CORTISONE(2,2,4,6,6,9,12,12-d8) 是 CORTISONE 的氘代化合物。CORTISONE 的 CAS 号为 53-06-5。Cortisone 是 Cortisol(一种糖皮质激素)的氧化代谢产物。Cortisone 具有消炎和免疫抑制的作用。Cortisone 在高浓度下对 Glucocorticoid 与Glucocorticoid-receptor的结合具有部分干预作用。 | |||
TMIJ-0338 |
Pitolisant-d6 HCl
|
||
Pitolisant-d6 HCl 是 Pitolisant HCl 的氘代化合物。Pitolisant HCl 的 CAS 号为 903576-44-3。Pitolisant hydrochloride 是一种有效的、选择性的组胺 H3 受体反向激动剂,Ki为0.16 nM。 | |||
TMIJ-0137 |
Tofacitinib-d3 Citrate
|
||
Tofacitinib-d3 Citrate 是 Tofacitinib Citrate 的氘代化合物。Tofacitinib Citrate 的 CAS 号为 540737-29-9。Tofacitinib citrate是JAK1/2/3抑制剂,IC50分别为112,20 和 1 nM。它具有抗菌,抗真菌和抗病毒活性。 | |||
TMIJ-0236 |
Vandetanib-d6
|
||
Vandetanib-d6 是 Vandetanib 的氘代化合物。Vandetanib 的 CAS 号为 443913-73-3。Vandetanib 是一种具有口服活性的VEGFR2/KDR酪氨酸激酶抑制剂,IC50值为40 nM。它也抑制VEGFR3/FLT4和EGFR/HER1,IC50值分别为110和500 nM。 | |||
TMIH-0361 |
N,N'-Dimethylarginine-d6
|
||
N,N'-Dimethylarginine-d6 是 N,N'-Dimethylarginine 的氘代化合物。N,N'-Dimethylarginine 的 CAS 号为 30344-00-4。SDMA 是一氧化氮 (NO) 合酶的内源性抑制剂。 | |||
TMIJ-0120 |
Donepezil-d5
|
||
Donepezil-d5 是 Donepezil 的氘代化合物。Donepezil 的 CAS 号为 120014-06-4。Donepezil 是一种AChE抑制剂,对牛 AChE 和人 AChE 的IC50分别为 8.12 nM 和 11.6 nM。 | |||
TMID-0012 |
Ethyl-d5 Vanillin
|
||
Ethyl-d5 Vanillin 是 Ethyl Vanillin 的氘代化合物。Ethyl Vanillin 的 CAS 号为 121-32-4。Ethyl vanillin 是一种食用香料,效果是 Vanillin 的三倍,可用于巧克力的生产。 | |||
TMIH-0302 |
Linagliptin-d4
|
||
Linagliptin-d4 是 Linagliptin 的氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂,具有降血糖活性。 | |||
TMIJ-0244 |
Fulvestrant-d3
|
||
Fulvestrant-d3 是 Fulvestrant 的氘代化合物。Fulvestrant 的 CAS 号为 129453-61-8。Fulvestrant是纯抗雌激素,也是一种雌激素受体拮抗剂,IC50为 9.4 nM。它抑制ER阳性 MCF-7 细胞的生长,IC50为 0.29 nM。它还是一种GPR30的激动剂。它可诱导细胞自噬和凋亡,有抗肿瘤作用。 | |||
TMIH-0394 |
Nirmatrelvir-d9
|
||
Nirmatrelvir-d9 是 Nirmatrelvir 的氘代化合物。Nirmatrelvir 的 CAS 号为 2628280-40-8。PF-07321332 是一种有效的口服活性SARS-CoV 3CLPRO抑制剂,对 SARS-CoV-2 病毒有针对性,可研究 COVID-19。它是一种胰蛋白酶样蛋白酶抑制剂,可抑制气道上皮钠通道功能。 | |||
TMID-0050 |
N-Desmethyl Sildenafil-d8
|
||
N-Desmethyl Sildenafil-d8 是 N-Desmethyl Sildenafil 的氘代化合物。N-Desmethyl Sildenafil 的 CAS 号为 139755-82-1。N-Desmethyl Sildenafil是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。 | |||
T73711 |
Atomoxetine-d3 hydrochloride
|
||
Atomoxetine-d3 hydrochloride 是氘代标记的Atomoxetine hydrochloride。Atomoxetine hydrochloride 是去甲肾上腺素重吸收抑制剂,与人NET,SERT 和DAT 的放射性配体结合的 Ki 分别为5,77和1451 nM。 | |||
TMIJ-0143 |
Linagliptin-13C-d3
|
||
Linagliptin-13C-d3 是 Linagliptin 的 13C 和氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂,具有降血糖活性。 | |||
T72818 |
Dosimertinib-d3
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Dosimertinib-d3是一种有效的口服活性EGFR 抑制剂。Dosimertinib-d3降低 p-EGFR 和 p-ERK 蛋白水平的表达。Dosimertinib-d3显示出抗增殖和抗肿瘤活性。Dosimertinib-d3具有非小细胞肺癌 (NSCLC) 研究的潜力。 | |||
T73715 |
Risperidone-d4
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Risperidone-d4是 Risperidone 的氘代物。Risperidone 是5-HT2受体的阻断剂,P-糖蛋白(P-Glycoprotein)的抑制剂 和dopamine D2受体的拮抗剂,其对 5-HT2A 和 dopamine D2受体的Ki 值分别为 4.8,5.9 nM。 | |||
TMID-0227 |
Rifabutin-d7
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Rifabutin-d7 是 Rifabutin 的氘代化合物。Rifabutin 的 CAS 号为 72559-06-9。Rifabutin是半合成的安莎霉素抗生素,抑制 DNA 依赖性 RNA 聚合酶,有抗分枝杆菌作用。 | |||
TMIJ-0116 |
Rupatadine-d4 Fumarate
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Rupatadine-d4 Fumarate 是 Rupatadine Fumarate 的氘代化合物。Rupatadine Fumarate 的 CAS 号为 182349-12-8。Rupatadine Fumarate 是一种可口服的长效PAF/H1受体的双抑制剂,Ki值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。 | |||
TMIJ-0235 |
rac-Tolterodine-d14 Tartrate
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rac-Tolterodine-d14 Tartrate 是 rac-Tolterodine Tartrate 的氘代化合物。rac-Tolterodine Tartrate 的 CAS 号为 124937-52-6。Tolterodine Tartrate 是毒蕈碱受体的有效拮抗剂。 它在体内显示出对膀胱和唾液腺的选择性。 | |||
TMIJ-0516 |
Carbaryl-d3
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Carbaryl-d3 是 Carbaryl 的氘代化合物。Carbaryl 的 CAS 号为 63-25-2。Carbaryl 可作为一种杀虫剂。 | |||
TMIJ-0108 |
rac-Hesperetin-13C-d3
rac-Diosmin EP Impurity G-13C-d3 |
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rac-Hesperetin-13C-d3 是 rac-Hesperetin 的 13C 和氘代化合物。rac-Hesperetin 的 CAS 号为 69097-99-0。 | |||
TMIJ-0273 |
Sulindac EP Impurity C-d3
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Sulindac EP Impurity C-d3 是 Sulindac EP Impurity C 的氘代化合物。Sulindac EP Impurity C 的 CAS 号为 32004-67-4。 | |||
TMIJ-0071 |
Oseltamivir-13C-d3 Acid
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Oseltamivir-13C-d3 Acid 是 Oseltamivir Acid 的 13C 和氘代化合物。Oseltamivir Acid 的 CAS 号为 187227-45-8。Oseltamivir acid是Oseltamivir phosphate 的活性代谢产物,是一种有效的流感病毒神经氨酸酶抑制剂和 GS4071 的前药。 | |||
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