Fantofarone (SR 33557) is a highly potent antagonist of Calcium Channel.

从所述内容可以看出，钙通道阻滞剂VIZ和Fantofarone（SR）与CQ相比具有较弱的内在抗疟疾特性，且在对抗CQ抵抗性寄生虫上比对抗CQ敏感性寄生虫略显更有效。值得注意的是，Fantofarone的效力大约是verapamil的10倍。Fantofarone（SR）对两种P. fdciparum菌株的效力是苯基烷胺类verapamil（VR）的10倍。根据同位图分析显示，这两种钙通道阻滞剂能增强对CQ抵抗性P. fufcipurum菌株的CQ敏感性活动，其中verapamil的效力比Fantofarone高出2到3倍。此外，在使用类似其IC50的亚抑制份额时，VR在降低CQ抗药性方面的效力比Fantofarone高出2到3倍。

在使用异硝酸异山梨酯（0.3 mg/kg，静脉注射）或Fantofarone（50 mg/kg，静脉注射）时，观察到血管痉挛发生率和严重度的降低，而verapamil（0.2 mg/kg，静脉注射）的效果则明显较弱。尽管异硝酸异山梨酯能完全抑制远端AIV，但对近端直径减少没有显著影响。在抑制远端和近端血管痉挛方面，有效的化合物是Fantofarone，它在整个实验中显著减少了AIV。相比之下，Verapamil未能显著减少AIV。

Male White rabbits are used in this study (3.0-3.2 kg). All surgical procedures are performed under anaesthesia with a mixture of ketamine and xylazine. At the end of the experiments, the animals are sacrificed by a pentobarbital overdose. The proximal femoral arteries are exposed, and the isolated arterial segments are desiccated by air infusion delivered at a rate of 80 mL/min for 8 min. After desiccation is completed, the ligatures are released and flow is restored. At the day of surgery, a 2% cholesterol/6% peanut oil diet is started for 2 weeks. Before angioplasty, the animals are randomized in 4 groups of 10 animals:1. Placebo, 1 mL/kg of NaCl 0.9%, 2. Isosorbide dinitrate, 0.3 mg/kg, 3. Verapamil, 0.2 mg/kg, 4. Fantofarone, 50 mg/kg. The doses of isosorbide dinitrate, verapamil, and fantofarone are defined in a pilot experiment as the highest doses which did not show any hypotensive effect per se and are chosen very carefully according to their activity measured in other pharmacological models.