Complete Freund's adjuvant is an immunoadjuvant emulsified with antigen that can enhance an animal's immune response to an antigen. Complete Freund's adjuvant is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant stimulates a strong and durable immune response and can be used to induce rheumatoid arthritis in rats, and more.

Complete Freund's adjuvant (1 mg/ml, 0.1 mL；皮下注射；每天一次，持续两天) 被用于诱导 Sprague-Dawley 大鼠的类风湿性关节炎。 动物模型: Sprague-Dawley 大鼠 [3]。剂量: 1 mg/ml, 0.1 mL。给药方式: 皮下注射；每天一次，持续两天。结果表现为胸腺和脾脏指数增加，GSH、CAT、SOD 和 MPO 活性降低，IL-1β、IL-6、IL-17、MCP-1、TNF-α、COX-2、5-LOX、NF-p65、IgG1 和 IgG2a 水平增加，IL-10 水平减少。