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HDAC-IN-30 是多种HDAC 蛋白的抑制剂,包括HDAC1(IC50=13.4 nM),HDAC2(IC50=28.0 nM),HDAC3(IC50=9.18 nM),HDAC6(IC50=42.7 nM),HDAC8(IC50=131 nM)。HDAC-IN-30 显示除强大的抗肿瘤作用。
HDAC-IN-30 是多种HDAC 蛋白的抑制剂,包括HDAC1(IC50=13.4 nM),HDAC2(IC50=28.0 nM),HDAC3(IC50=9.18 nM),HDAC6(IC50=42.7 nM),HDAC8(IC50=131 nM)。HDAC-IN-30 显示除强大的抗肿瘤作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | HDAC-IN-30 is a multi-target HDAC inhibitor. HDAC-IN-30 inhibits HDAC1 (IC50 =13.4 nM), HDAC2 (IC50 =28.0 nM), HDAC3 (IC50 =9.18 nM), HDAC6 (IC50 =42.7 nM), HDAC8 (IC50 =131 nM). HDAC-IN-30 shows potent antitumor efficacy. |
体外活性 | HDAC-IN-30 (compound 8 h; 0.5, 1, 2 μM; 48 hours) can effectively activate the p53 pathway by promoting the phosphorylation of p53 [1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours; HepG2 cells) induces cell cycle arrest at the G2 phase in a concentration-dependent manner [1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours) possesses prominent anticancer activity in HepG2 cells [1]. Western Blot Analysis [1] Cell Line: HepG2 cells Concentration: 0.5, 1, 2 μM Incubation Time: 24 hours Result: Could effectively activate the p53 pathway by promoting the phosphorylation of p53 Cell Cycle Analysis [1] Cell Line: HepG2 cells Concentration: 0, 1, 2.5, 5 μM Incubation Time: 48 hours Result: Cells were arrested at the G2 phase in a dose-dependent manner. Apoptosis Analysis [1] Cell Line: HepG2 cells Concentration: 0, 1, 2.5, 5 μM Incubation Time: 24 hours Result: Possessed prominent anticancer activity in HepG2 cells. |
体内活性 | HDAC-IN-30 (12, 24 mg/kg; intraperitoneal injection, every two days for 4 weeks) exhibits potent anticancer activity and no side effects even at high dose (24 mg/kg) [1]. Animal Model: HepG2 xenograft mouse model [1] Dosage: 12, 24 mg/kg Administration: Intraperitoneal injection, every 2 days, 4 weeks Result: Exhibited potent anticancer activity |
分子量 | 405.45 |
分子式 | C22H23N5O3 |
CAS No. | 2756809-34-2 |
存储 | keep away from moisture | Shipping with blue ice. |
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