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(S)-Sabutoclax ((S)-BI-97C1) 作为一种光学纯的阿朴棉酚衍生物,对抗凋亡B细胞淋巴瘤/白血病2 (Bcl-2) 家族蛋白展现了全谱抑制作用。该化合物通过阻断BH3肽与Bcl-XL、Bcl-2、Mcl-1及Bfl-1的结合,展示出相应的IC50值为0.31、0.32、0.20及0.62 μM。此外,(S)-Sabutoclax还能有效抑制人类前列腺癌、肺癌以及淋巴瘤细胞系的生长,其EC50值分别为0.13、0.56及0.049 μM。因此,(S)-Sabutoclax对于基于细胞凋亡机制的癌症治疗研究具有重要价值。
(S)-Sabutoclax ((S)-BI-97C1) 作为一种光学纯的阿朴棉酚衍生物,对抗凋亡B细胞淋巴瘤/白血病2 (Bcl-2) 家族蛋白展现了全谱抑制作用。该化合物通过阻断BH3肽与Bcl-XL、Bcl-2、Mcl-1及Bfl-1的结合,展示出相应的IC50值为0.31、0.32、0.20及0.62 μM。此外,(S)-Sabutoclax还能有效抑制人类前列腺癌、肺癌以及淋巴瘤细胞系的生长,其EC50值分别为0.13、0.56及0.049 μM。因此,(S)-Sabutoclax对于基于细胞凋亡机制的癌症治疗研究具有重要价值。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 8-10周 | |
50 mg | 询价 | 8-10周 |
产品描述 | (S)-Sabutoclax ((S)-BI-97C1), an optically pure derivative of apogossypol, serves as a pan-active inhibitor of the antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. It effectively blocks the binding of BH3 peptides to key proteins in the family, including Bcl-XL, Bcl-2, Mcl-1, and Bfl-1, displaying inhibitory concentration (IC50) values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. Furthermore, (S)-Sabutoclax demonstrates potent efficacy in inhibiting the growth of various cancer cell lines, such as those from human prostate cancer, lung cancer, and lymphoma, with half-maximal effective concentration (EC50) values of 0.13, 0.56, and 0.049 μM, respectively. This compound is utilized in research focusing on apoptosis-based cancer therapies [1]. |
别名 | (S)-BI-97C1 |
分子量 | 732.84 |
分子式 | C42H42N2O8S |
CAS No. | 1228178-73-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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