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HSD17B13-IN-17 (compound 9) 作为一种对 hydroxysteroid 17?-dehydrogenase 13 (HSD17B13) 高效的抑制剂,显示出在雌二醇和白三烯 B3 的IC50值分别小于 0.1 μM 和小于 1 μM。它在非酒精性脂肪性肝病 (NAFLD),包括 NASH(非酒精性脂肪性肝炎)的研究中扮演着重要角色。
HSD17B13-IN-17 (compound 9) 作为一种对 hydroxysteroid 17?-dehydrogenase 13 (HSD17B13) 高效的抑制剂,显示出在雌二醇和白三烯 B3 的IC50值分别小于 0.1 μM 和小于 1 μM。它在非酒精性脂肪性肝病 (NAFLD),包括 NASH(非酒精性脂肪性肝炎)的研究中扮演着重要角色。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It demonstrates inhibitory efficacy with IC50 values of <0.1 μM for estradiol and <1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1]. |
分子量 | 418.87 |
分子式 | C20H16ClFN2O3S |
CAS No. | 2758802-10-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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