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Tyrosinase-IN-2

Name: Tyrosinase-IN-2
Brand: TargetMol
SKU: T60278
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T60278Cas号 180864-33-9 一键复制产品信息纯度: 99.78%

很棒

Tyrosinase-IN-2 (compound 67) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种含铜金属酶，负责黑色素生物合成和酶促褐变中的限速催化步骤。Tyrosinase-IN-2 具有研究皮肤美白剂和食品防腐剂的潜力。

Tyrosinase-IN-2

一键复制产品信息

很棒

纯度: 99.78%

货号 T60278Cas号 180864-33-9

规格	价格	库存
2 mg	¥ 145	现货
5 mg	¥ 248	现货
10 mg	¥ 403	现货
25 mg	¥ 833	现货
50 mg	¥ 1,330	现货
100 mg	¥ 1,960	现货
1 mL x 10 mM (in DMSO)	¥ 280	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.78%

颜色: 黄色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Tyrosinase-IN-2 AI Summary

Tyrosinase-IN-2 exhibits a wide range of bioactivities against several parasites and enzymes, showing significant potential as an anti-parasitic and multi-target therapeutic agent. It demonstrates anti-parasitic activity against Toxoplasma gondii, reducing the number of intracellular parasites in infected vero cells, with IC50 values of 1,500,000 nM and 500,000 nM for the infected cells and parasites, respectively. The compound also inhibits the trypomastigote and amastigote stages of Trypanosoma cruzi Y, with EC50 values of 1,430.0 nM and 3,230.0 nM, respectively, and selectivity indices of 26.2 and 11.6, indicating specificity towards the parasite over mammalian cells. Additionally, Tyrosinase-IN-2 shows various inhibitory activities: against jack bean urease (IC50 547.0 nM, Ki 497.0 nM), mushroom tyrosinase (IC50 1740.0 nM for diphenolase and 50.0 nM for monophenolase), and human ERG, along with inhibition of human microsomal CYP enzymes and recombinant human aurora B kinase. It also addresses multiple bacterial and viral targets, including inhibition of AmpC Beta-Lactamase, ROR gamma transcriptional activity, and Vaccinia Orthopoxvirus. The compound exhibits cytotoxicity against different human cell lines but also potentiates methotrexate-induced antitrypanosomal activity and displays permeability in PAMPA assays. This diverse bioactivity profile hints at its potential utility in treating multiple diseases, particularly parasitic infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme pivotal for the catalytic step that limits the rate in melanin biosynthesis and enzymatic browning processes. This compound holds potential for research into skin whitening agents and food preservatives [1].

化学信息

分子量	224.24
分子式	C₈H₈N₄O₂S
CAS No.	180864-33-9
Smiles	NC(=S)N\N=C\c1ccc(cc1)[N+]([O-])=O

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (222.98 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4595 mL	22.2975 mL	44.5951 mL	222.9754 mL
5 mM	0.8919 mL	4.4595 mL	8.9190 mL	44.5951 mL
10 mM	0.4460 mL	2.2298 mL	4.4595 mL	22.2975 mL
20 mM	0.2230 mL	1.1149 mL	2.2298 mL	11.1488 mL
50 mM	0.0892 mL	0.4460 mL	0.8919 mL	4.4595 mL
100 mM	0.0446 mL	0.2230 mL	0.4460 mL	2.2298 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。