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ASP2453是选择性的KRAS G12C 共价抑制剂,抑制Son of Sevenless 介导的KRAS G12C 和Raf 之间的相互作用,IC50为40 nM。
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ASP2453是选择性的KRAS G12C 共价抑制剂,抑制Son of Sevenless 介导的KRAS G12C 和Raf 之间的相互作用,IC50为40 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,180 | 现货 | |
5 mg | ¥ 2,930 | 现货 | |
10 mg | ¥ 3,970 | 现货 | |
25 mg | ¥ 5,920 | 现货 | |
50 mg | ¥ 8,280 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 4,570 | 现货 |
产品描述 | ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM. |
靶点活性 | KRas (G12C):40 nM (IC50) |
分子量 | 747.85 |
分子式 | C40H48F3N7O4 |
CAS No. | 2241719-73-1 |
Smiles | COCCCN1CCC(CC1)Oc1nc(N2CCC3(CN(C3)C(=O)C=C)CC2)c2cc(C3CC3)c(c(OCC(F)(F)F)c2n1)-c1c(C)ccc2[nH]ncc12 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 250 mg/mL (334.29 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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