Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, and specific tetrapeptide interleukin-1β converting enzyme (ICE) inhibitor, demonstrating specificity for caspase-1 as well. It exhibits K_i values of 3.0 nM in mice and 0.76 nM in humans, underscoring its efficacy. Additionally, Ac-YVAD-CHO acetate has the capacity to inhibit the production of mature IL-1β, highlighting its therapeutic potential [1] [2] [3].