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ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。
ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 497 | 现货 | |
10 mg | ¥ 797 | 现货 | |
25 mg | ¥ 1,620 | 现货 | |
50 mg | ¥ 2,390 | 现货 | |
100 mg | ¥ 3,600 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 728 | 现货 |
产品描述 | ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway-specific p97 inhibitors. |
靶点活性 | p97:100 nM |
体外活性 | ML241对HCT15和SW403细胞表现出细胞毒性,其GI50分别为经过24小时处理后的53μM和33μM,以及经过72小时处理后的13μM和12μM。 |
细胞实验 | HeLa cells stably expressing ODD-luciferase are seeded onto a 96-well white solid bottom plate (5000 cells/well) and cells are grown for 16 h. Cells are treated with DMEM containing MG132 (4 μM) for 1h and washed with 100 μL PBS twice. DMEM containing 2.5% FBS, cycloheximide (50 μg/mL) and ML241 are added into the well. Four 96-well plates are prepared and one of the plates is taken out from incubator at each time point (70, 90, 120, or 150 min). Luciferin (50 μL of 1 mg/mL in PBS) is added into each well containing 50 μL of medium and incubated at room temperature with shaking at 500 rpm for 5 min. Luminescence intensity is determined with 0.1 ms integration time on the Synergy HT Microplate Reader |
分子量 | 408.92 |
分子式 | C23H25ClN4O |
CAS No. | 2070015-13-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (122.27 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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