AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrates excellent in vitro blood-brain barrier (BBB) permeability [1].

AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE [1].

AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice [1]. Animal Model: Kunming mice at body weight of 18–22 g (male and female in half) [1] Dosage: 1.0, 5.0 and 25.0 mg/kg Administration: Intragastric administration, once a day for 7 consecutive days Result: Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.