HB007

Name: HB007
Brand: TargetMol
SKU: T37646
Price: 1980 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T37646Cas号 2387821-46-5

HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].

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HB007

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产品编号 T37646Cas号 2387821-46-5

规格	价格	库存
2 mg	¥ 1,470	5日内发货
5 mg	¥ 2,490	5日内发货
25 mg	¥ 8,620	6-8周
50 mg	¥ 11,200	6-8周
100 mg	¥ 17,400	6-8周
1 mL x 10 mM (in DMSO)	¥ 2,730	5日内发货

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产品介绍

生物活性

产品描述	HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
体外活性	HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].
体内活性	HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].