TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficits in an Alzheimer's disease (AD) mouse model, thus serving as a valuable tool for Alzheimer’s disease research [1].

TrkB-IN-1（经口灌胃；7.25 mg/kg、21.8 mg/kg、43.6 mg/kg；3个月）在5XFAD小鼠中呈剂量依赖性地激活海马TrkB信号通路，并提高了p-TrkB/TrkB、p-Akt/Akt和p-ERK/ERK的比例[1]。TrkB-IN-1（经口灌胃；7.25 mg/kg、21.8 mg/kg、43.6 mg/kg；5天）能够减少5XFAD小鼠的Aβ沉积，并有助于恢复记忆缺失[1]。此外，TrkB-IN-1（经口灌胃；36 mg/kg）的口服生物利用度为10.5%，C max达到129 ng/mL，T max为0.5小时，T 1/2为3.66小时[1]。