Pyripyropene A

Name: Pyripyropene A
Brand: TargetMol
SKU: T12592
Rating: 4.5 (1 reviews)

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产品编号 T12592Cas号 147444-03-9

Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).

Pyripyropene A

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产品编号 T12592Cas号 147444-03-9

Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).

规格	价格	库存
25 mg	¥ 42,180	10-14周
50 mg	¥ 67,500	10-14周
100 mg	¥ 108,000	10-14周

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产品描述	Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).
靶点活性	ACAT2:0.07 µM
体外活性	Pyripyropene A inhibits VEGF (20 ng/ml)-induced migration and tubular formation of HUVECs in dose-dependent fashion. Pyripyropene A do not show growth inhibitory effects against KB3-1, K562 and Neuro2A cells.Pyripyropene A exhibits anti-proliferative activity against HUVECs(IC50 value of 1.8 μM)[1].
体内活性	Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart. Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2 (ACAT2) activity in vivo[3]. Pyripyropene A displays a half-life (t1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile[4].