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BMS-986224 是一种具有口服活性、有效性和选择性的 APJ 受体激动剂。BMS-986224 具有研究心力衰竭的潜力。
BMS-986224 是一种具有口服活性、有效性和选择性的 APJ 受体激动剂。BMS-986224 具有研究心力衰竭的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 2,499 | 现货 |
产品描述 | BMS-986224 is an orally active, potent, and selective APJ receptor agonist. BMS-986224 has the potential to study heart failure. |
靶点活性 | APJ receptor:0.02 nM (EC50, human), APJ receptor:0.3 nM (Kd) |
体外活性 | Fully inhibits forskolin-mediated cAMP production, with an EC50 for human APJ of 0.02 nM, BMS-986224. BMS-986224 (0-100 nM) fully stimulates β-arrestin recruitment, ERK phosphorylation, and APJ internalization in Chinese hamster ovary-K1 or HEK293 ZF cells. BMS-986224 is a potent and selective APJ receptor agonist that exhibits a similar signaling profile to (Pyr1) apelin-13. |
体内活性 | In the RHR model, BMS-986224 (0.192 mg/kg or 3 mg/kg; SC infusion; daily) increased stroke volume and cardiac output to levels seen in healthy animals, but without preventing cardiac hypertrophy and fibrosis. These effects are differentiated from enalapril[1]. |
别名 | BMS 986224 |
分子量 | 498.92 |
分子式 | C24H23ClN4O6 |
CAS No. | 2055200-88-7 |
Smiles | CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(Cl)cn3)o2)c(O)c1-c1c(OC)cccc1OC |
密度 | 1.366 g/cm3 (Predicted) |
存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 10 mg/mL (20.04 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
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