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CEP28122 是一种高效的、选择性的 ALK 抑制剂 (IC50:1.9 ± 0.5 nM)。
CEP28122 是一种高效的、选择性的 ALK 抑制剂 (IC50:1.9 ± 0.5 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 488 | 1-2周 | |
2 mg | ¥ 732 | 1-2周 | |
5 mg | ¥ 1,317 | 1-2周 | |
10 mg | ¥ 2,127 | 1-2周 | |
25 mg | ¥ 3,829 | 1-2周 |
产品描述 | CEP-28122 is a highly potent and selective orally active ALK inhibitor. |
靶点活性 | ALK:1.9 ± 0.5 nM |
激酶实验 | Flashplate assay for identification and evaluation of Aurora inhibitors: On this assay 384-well Basic Flashplate? as solid assay platform is used. The plates are coated overnight at 4 °C with dithiothreitol (DTT) at 100 μg/mL in PBS buffer and used after being washed twice with PBS. 5 μL of CCT137690 in 2% DMSO is added to each well followed by 15 μL master mix of kinase buffer (50 mM Tris pH 7.5, 10 mM NaCl, 2.5 mM MgCl2, 1 mM myelin basic protein (MBP), 20 μM ATP, and 0.025 μCi/μL 33P-ATP). Finally, 250 ng per well of Aurora-A enzyme is added. The plate is shaken for approximately 2 min on a flat-bed plate shaker and incubated for 2 hours at room temperature. The reaction is stopped by washing the plate twice on a 16-pin wash with 10 mM sodium pyrophosphate. The plate is then read on a TopCount-NXTTM. For the determination of the inhibitory activity against Aurora-B or Aurora-C, the same conditions are followed in the assay using Aurora-B or Aurora-C enzymes. |
分子量 | 539.07 |
分子式 | C28H35ClN6O3 |
CAS No. | 1022958-60-6 |
Smiles | N([C@@H]1[C@@]2(C[C@]([C@@H]1C(N)=O)(C=C2)[H])[H])C3=NC(NC=4C(OC)=C5C(=CC4)CC[C@@H](CC5)N6CCOCC6)=NC=C3Cl |
密度 | 1.357 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 10 mM | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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