NCT-501 hydrochloride

Name: NCT-501 hydrochloride
Brand: TargetMol
SKU: T39485
Rating: 4.5 (1 reviews)

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产品编号 T39485Cas号 2080306-22-3

NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).

NCT-501 hydrochloride

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产品编号 T39485Cas号 2080306-22-3

规格	价格	库存
1 mg	¥ 997	35日内发货
5 mg	¥ 3,970	35日内发货
10 mg	¥ 6,740	35日内发货
25 mg	¥ 15,500	35日内发货

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产品描述	NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
靶点活性	ALDH1A1 (human):40 nM (IC50)
体外活性	NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant[1].
体内活性	NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts[1].