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8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 μg | ¥ 980 | 35日内发货 | |
1 mg | ¥ 1,830 | 35日内发货 | |
5 mg | ¥ 7,500 | 35日内发货 | |
10 mg | ¥ 13,000 | 35日内发货 |
产品描述 | 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure. |
别名 | 8-iso Prostaglandin E2 |
分子量 | 352.47 |
分子式 | C20H32O5 |
CAS No. | 27415-25-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | PBS (pH 7.2): >5 mg/mL (from PGE2) DMSO: >100 mg/mL (from PGE2) Ethanol: >100 mg/mL (from PGE2) DMF: >100 mg/mL (from PGE2) |
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