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JNJ-17203212 是一种竞争性 TRPV1选择性拮抗剂。它被开发用于疼痛处理的研究。
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JNJ-17203212 是一种竞争性 TRPV1选择性拮抗剂。它被开发用于疼痛处理的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 283 | 现货 | |
5 mg | ¥ 662 | 现货 | |
10 mg | ¥ 1,160 | 现货 | |
25 mg | ¥ 2,650 | 现货 | |
50 mg | ¥ 4,290 | 现货 | |
100 mg | ¥ 5,970 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 728 | 现货 |
产品描述 | JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM). |
靶点活性 | TRPV1 (rat):102 nM, TRPV1 (human):65 nM |
体内活性 | TRPV1 antagonist, JNJ-17203212, reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity.??TRPV1 is involved in the pathogenesis of visceral hypersensitivity and that JNJ-17203212 may be a potential therapeutic agent for functional bowel disorders characterized by abdominal hypersensitivity, such as irritable bowel syndrome[1]. |
动物实验 | Colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle[1]. |
分子量 | 419.32 |
分子式 | C17H15F6N5O |
CAS No. | 821768-06-3 |
Smiles | FC(F)(F)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2C(F)(F)F)nc1 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (238.48 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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