MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1).

SPIN1:77 nM , SPIN1:243 nM , SPIN1:(kd)91 nM

MS31(compound 3) is a potent, selective, and cell-active SPIN1 inhibitor, Compound 3 potently inhibited binding of trimethyllysine-containing peptides to SPIN1, displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers and writers, directly engaged SPIN1 in cells, and was not toxic to nontumorigenic cells[1].