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6',7'-Epoxybergamottin
产品编号 T37810Cas号 206978-14-5
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.
6',7'-Epoxybergamottin
产品编号 T37810Cas号 206978-14-5
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 788 | 35日内发货 | |
| 5 mg | ¥ 2,960 | 35日内发货 | |
| 10 mg | ¥ 5,630 | 35日内发货 |
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产品介绍
生物活性
化学信息
| 产品描述 | 6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transporter substrate, across Caco-2 cell monolayers (IC50 = 0.7 μM). 6'7'-Epoxybergamottin also has insecticidal properties with a concentration of 5 μg/cm2 leading to 100% mortality of adult olive fruit flies. |
| 分子量 | 354.4 |
| 分子式 | C21H22O5 |
| CAS No. | 206978-14-5 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度信息 | DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL Ethanol: 10 mg/mL DMSO: 30 mg/mL DMF: 30 mg/mL |
TCMIP相关数据
中药材来源及性味归经
所属中成药
所属中药方剂
| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 代代花 | Citrus aurantium L.var.amara Engl.[C.aurantium ‘Daidai’] | 平 | 辛, 甘, 微苦 | 肝, 胃 |
| 酸橙 | Citrus aurantium L. | 寒 | 酸 |
| 中成药名称 | 处方组成 | 中成药类型 |
|---|---|---|
| 小儿增食丸 | 山楂,六神曲,麦芽,焦槟榔,黄芩,化橘红,砂仁,枳壳,代代花,鸡内金,莱菔子 | 消食化积 |
| 肝郁调经膏 | 白芍,佛手,郁金,玫瑰花,代代花,牡丹皮,川楝子,香附,当归,丹参,葛根,泽泻 | 理气药 |
| 方剂名称 | 处方组成 | 剂型 | 处方来源 |
|---|
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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