PTPN22-IN-1

Name: PTPN22-IN-1
Brand: TargetMol
SKU: T40216
Rating: 4.5 (1 reviews)

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产品编号 T40216Cas号 2580935-57-3

别名 PTPN22-IN-1

PTPN22-IN-1 is a potent PTPN22 inhibitor ( IC 50 =1.4 μM; K i =0.50 μM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1.

PTPN22-IN-1

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产品编号 T40216 别名 PTPN22-IN-1Cas号 2580935-57-3

规格	价格	库存	数量
2 mg	¥ 2,890	5日内发货

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生物活性

产品描述	PTPN22-IN-1, detailed in WO2021007491A1 as compound L-1, is a potent PTPN22 inhibitor, demonstrating an IC50 of 1.4 μM and a Ki of 0.50 μM. This compound achieves over 7-10 fold selectivity against PTPN22 relative to comparable phosphatases and enhances antitumor immune responses.
体外活性	PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1]. Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 μM h and C max of 1.1 1 μM (Fig. 9d), which is more than twice of its K i value[1].
体内活性	PTPN22-IN-1 (Compound L-1) (WT mice; intraperitoneally) significantly reduces MC38 tumor growth. PTPN22-IN-1 (syngeneic immunocompetent model; CT26 in Balb/c mice) shows similar antitumor effects[1]. Administration of L-l intraperitoneally at 10 mg/kg yielded an average AUC of 4.55 μM h and C max of 1.1 1 μM (Fig. 9d), which is more than twice of its K i value[1].
别名	PTPN22-IN-1