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BSO-07作为一种有效的ROS/JNK激活剂,在抗癌领域展现出显著效果,对人类乳腺癌(BC)细胞的IC50值为24.81 μM。该化合物通过促进JNK的活化和ROS水平的增加,有效诱导癌细胞的凋亡(Apoptosis)和致瘤性凋亡。其机制包括上调凋亡相关蛋白(诸如PARP、Bax、磷酸化的p53、ATF4和CHOP)的表达,并下调抗凋亡蛋白(如Bcl-2、Bcl-xL和Survivin)的水平。BSO-07为乳腺癌研究提供了新的研究方向。
BSO-07作为一种有效的ROS/JNK激活剂,在抗癌领域展现出显著效果,对人类乳腺癌(BC)细胞的IC50值为24.81 μM。该化合物通过促进JNK的活化和ROS水平的增加,有效诱导癌细胞的凋亡(Apoptosis)和致瘤性凋亡。其机制包括上调凋亡相关蛋白(诸如PARP、Bax、磷酸化的p53、ATF4和CHOP)的表达,并下调抗凋亡蛋白(如Bcl-2、Bcl-xL和Survivin)的水平。BSO-07为乳腺癌研究提供了新的研究方向。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | BSO-07 is a ROS/JNK activator that exhibits potent anti-cancer properties, demonstrated by an IC50 of 24.81 μM in human breast cancer (BC) cells. The mechanism of action for BSO-07 involves JNK activation and the promotion of increased ROS levels, which lead to the induction of apoptosis (Apoptosis) and tumorigenic apoptosis. This includes enhanced expression of apoptosis-related proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, along with a reduction in the levels of anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL, and Survivin). BSO-07 holds promise for research in the field of breast cancer. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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