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SAP15(Synthetic anti-inflammatory peptide 15),一种由15个氨基酸组成的合成抗炎肽,源自于人类β-防御素3设计。该肽具备穿透细胞的能力,能诱导细胞内炎症反应的下调。它通过抑制HDAC5的磷酸化来减少NF-κBp65的磷酸化,从而抑制炎症反应。在LPS诱导的巨噬细胞中,SAP15能有效抑制HDAC5和NF-κBp65的磷酸化。此外,SAP15处理能促进LPS诱导的软骨细胞中aggrecan与II型胶原的表达,并降低骨钙素的表达。SAP15适用于用于研究生物材料中的炎症调节和抗炎治疗。
SAP15(Synthetic anti-inflammatory peptide 15),一种由15个氨基酸组成的合成抗炎肽,源自于人类β-防御素3设计。该肽具备穿透细胞的能力,能诱导细胞内炎症反应的下调。它通过抑制HDAC5的磷酸化来减少NF-κBp65的磷酸化,从而抑制炎症反应。在LPS诱导的巨噬细胞中,SAP15能有效抑制HDAC5和NF-κBp65的磷酸化。此外,SAP15处理能促进LPS诱导的软骨细胞中aggrecan与II型胶原的表达,并降低骨钙素的表达。SAP15适用于用于研究生物材料中的炎症调节和抗炎治疗。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic peptide composed of 15 amino acids, derived from human beta-defensin 3, with the ability to penetrate cells and mitigate intracellular inflammation. It achieves its anti-inflammatory effects by blocking the phosphorylation of HDAC5, which in turn reduces NF-κB p65 phosphorylation. In macrophages stimulated with LPS, SAP15 suppresses the phosphorylation of both HDAC5 and NF-κB p65, demonstrating potent anti-inflammatory actions. Furthermore, treatment with SAP15 in LPS-induced chondrocytes elevates aggrecan and type II collagen levels while reducing osteocalcin expression. This peptide is valuable for exploring inflammation regulation and the development of anti-inflammatory therapies in biomaterials . |
别名 | Synthetic anti-inflammatory peptide 15 |
分子量 | 1767.16 |
分子式 | C68H131N31O18S3 |
CAS No. | 1403753-45-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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