Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition.Osocimab is often used as an XI factor inhibitor, has an inhibitory effect on thrombin generation, has an anticoagulant effect, and is used in the study of thromboembolic diseases. Thromboembolic Diseases

Substrate cleavage (FXIa mediated):1.2 nM, FIX activation:16 nM

在人体血浆中，Osocimab (1.4 nM-1 μM; 30分钟) 对凝血酶产生展现了抑制作用，同时也抑制了FXIa介导的FIX激活（或FIX转化）和FXIa介导的底物裂解，其IC50分别为16 nM和1.2 nM [1]。Osocimab的浓度达到22.05 mg/mL时，能够抑制内源途径介导的凝血级联反应的激活[1]。