THI0019

Name: THI0019
Brand: TargetMol
SKU: T38793
Rating: 4.5 (1 reviews)

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产品编号 T38793Cas号 1378532-99-0

别名 THI0019

THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins.

THI0019

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产品编号 T38793 别名 THI0019Cas号 1378532-99-0

规格	价格	库存	数量
25 mg	¥ 9,880	6-8周
50 mg	¥ 12,837	6-8周

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生物活性

产品描述	THI0019 is a highly potent agonist of the integrin α4β1 (VLA-4) receptor, with an EC 50 range of 1-2 μM. It effectively promotes the adhesion of stem/progenitor cells. Furthermore, THI0019 successfully modulates adhesion processes mediated by α4β7, α5β1, and αLβ2 integrins.
靶点活性	α4β1:1-2 μM (EC50)
体外活性	In cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA, THI0019 shows a dose-dependent enhancement in cell binding with an EC 50 of 1.7 μM. When VCAM-1 is used as the ligand, THI0019 induces an even more pronounced 100-fold increase in Jurkat cell binding, with an EC 50 of 1.2 μM. THI0019 induces a dose-dependent increase in EPC binding to VCAM-1 (EC 50 of 3.7 μM). THI0019 facilitates the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α[1].
别名	THI0019