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Thioquinapiperifil dihydrochloride 是一种磷酸二酯酶(PDE-5)抑制剂(IC50: 0.074 nM),具有有效性、选择性和非竞争性,可用于研究性成熟。
Thioquinapiperifil dihydrochloride 是一种磷酸二酯酶(PDE-5)抑制剂(IC50: 0.074 nM),具有有效性、选择性和非竞争性,可用于研究性成熟。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,230 | 现货 | |
5 mg | ¥ 3,150 | 现货 | |
10 mg | ¥ 4,560 | 现货 | |
25 mg | ¥ 6,910 | 现货 | |
50 mg | ¥ 9,480 | 现货 | |
100 mg | ¥ 12,800 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 3,590 | 现货 |
产品描述 | Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation. |
靶点活性 | PDE1:380 nM, PDE4:800 nM, PDE5:0.074 nM, PDE3:38 nM, PDE2:670 nM |
体外活性 | Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) inhibits platelet aggregation in a concentration-dependent manner. In the absence of nitroglycerin, higher concentrations of 1 and 10 μM of KF31327 are inhibits platelet aggregation in a concentration-dependent manner.[2] Thioquinapiperifil dihydrochloride (KF31327) shows a significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of KF31327-treated cells is 0.95±0.17 pmol/10 8 cells.[2] |
别名 | KF-31327 |
分子量 | 485.05 |
分子式 | C24H29ClN6OS |
CAS No. | 204077-66-7 |
Smiles | Cl.Cl.CCn1c2cc3ncnc(NCc4ccccc4N4CCC(CO)CC4)c3cc2[nH]c1=S |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 112.5 mg/mL (215.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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