Forodesine hydrochloride

Name: Forodesine hydrochloride
Brand: TargetMol
SKU: T11313
Price: 412 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T11313Cas号 284490-13-7

别名 Immucillin-H hydrochloride, BCX-1777 hydrochloride

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

Forodesine hydrochloride

还可以

产品编号 T11313 别名 Immucillin-H hydrochloride, BCX-1777 hydrochlorideCas号 284490-13-7

规格	价格	库存	数量
5 mg	¥ 12,980	10-14周
100 mg	询价	10-14周

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产品介绍

生物活性

产品描述	Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
靶点活性	PNP (human):1.19 nM , PNP (monkey):0.66 nM , PNP (mouse):0.48 nM , PNP (rat):1.24 nM , PNP (dog):1.57 nM
体外活性	Forodesine (BCX-1777), in the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), inhibits human lymphocyte proliferation activated by various agents such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values
体内活性	n the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model, Forodesine is effective in prolonging the life span 2-fold or more.Forodesine (BCX-1777) has excellent oral bioavailability (63%) in mice.?At a single dose of 10 mg/kg in mice, Forodesine elevates dGuo to approximately 5 μM.
别名	Immucillin-H hydrochloride, BCX-1777 hydrochloride

化学信息

分子量	302.71
分子式	C₁₁H₁₅ClN₄O₄
CAS No.	284490-13-7
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 16.67 mg/mL (55.07 mM), Sonication is recommended.

H2O: 16.67 mg/mL (55.07 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	3.3035 mL	16.5175 mL	33.0349 mL	165.1746 mL
5 mM	0.6607 mL	3.3035 mL	6.6070 mL	33.0349 mL
10 mM	0.3303 mL	1.6517 mL	3.3035 mL	16.5175 mL
20 mM	0.1652 mL	0.8259 mL	1.6517 mL	8.2587 mL
50 mM	0.0661 mL	0.3303 mL	0.6607 mL	3.3035 mL