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顶部生物活性储存和溶解信息计算器

PAR2 (1-6) amide (human) (trifluoroacetate salt)

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产品编号 T35955Cas号 2379569-17-0
别名 PAR2 (1-6) amide (human) (trifluoroacetate salt)

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4

PAR2 (1-6) amide (human) (trifluoroacetate salt)
其他形式的 “PAR2 (1-6) amide (human) (trifluoroacetate salt)”:
PAR2 (1-6) (mouse, rat)T36531164081-25-8
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PAR2 (1-6) amide (human) (trifluoroacetate salt)

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产品编号 T35955 别名 PAR2 (1-6) amide (human) (trifluoroacetate salt)Cas号 2379569-17-0

PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4

规格价格库存数量
5 mg
¥ 1,560
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10 mg
¥ 2,850
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25 mg
¥ 5,930
35日内发货
50 mg
¥ 11,300
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产品介绍

生物活性
产品描述
PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-length sequence.1It binds to NCTC 2544 cells expressing human PAR2 (Ki= 9.64 μM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50= 0.075 μM).2PAR2 (1-6) amide (100 μM) reduces colony formation of A549 lung cancer cells.1It induces superoxide production and degranulation in isolated human eosinophils when used at a concentration of 500 μM.3PAR2 (1-6) amide (5 μmol/kg) induces tear secretion in rats when used in combination with amastatin .4
别名PAR2 (1-6) amide (human) (trifluoroacetate salt)
化学信息
分子量728.812
分子式C30H55F3N8O9
CAS No.2379569-17-0
储存&溶解度
存储keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Ethanol: 5 mg/mL (6.86 mM), Sonication is recommended.
DMF: 30 mg/mL (41.16 mM), Sonication is recommended.
DMSO: 15 mg/mL (20.58 mM), Sonication is recommended.
PBS (pH 7.2): 10 mg/mL (13.72 mM), Sonication is recommended.
溶液配制表
Ethanol/PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
1 mM1.3721 mL6.8605 mL13.7210 mL68.6048 mL
5 mM0.2744 mL1.3721 mL2.7442 mL13.7210 mL
PBS (pH 7.2)/DMSO/DMF
1mg5mg10mg50mg
10 mM0.1372 mL0.6860 mL1.3721 mL6.8605 mL
DMSO/DMF
1mg5mg10mg50mg
20 mM0.0686 mL0.3430 mL0.6860 mL3.4302 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments 一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300/ PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

PAR2 (16) amide (human) (trifluoroacetate salt)PAR-2 (1-6) amide (human) (trifluoroacetate salt)PAR 2PAR2 (1 6) amide (human) (trifluoroacetate salt)PAR2 AmidePAR-2PAR2

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