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UAMC-3203

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产品编号 T5343Cas号 2271358-64-4
别名 UAMC3203, UAMC 3203

UAMC-3203 是一种有效的选择性铁死亡抑制剂,IC50为12 nM。

UAMC-3203

UAMC-3203

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纯度: 100%
产品编号 T5343 别名 UAMC3203, UAMC 3203Cas号 2271358-64-4

UAMC-3203 是一种有效的选择性铁死亡抑制剂,IC50为12 nM。

规格价格库存数量
1 mg¥ 189现货
5 mg¥ 428现货
10 mg¥ 688现货
25 mg¥ 1,130现货
50 mg¥ 1,680现货
100 mg¥ 2,530现货
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产品介绍

生物活性
产品描述
UAMC-3203 is a potent and selective Ferroptosis inhibitor (IC50: 12 nM).
靶点活性
Ferroptosis:12 nM ( in IMR32 Neuroblastoma cells)
体外活性
UAMC-3203 exhibits even lower IC50-values (10 nM in IMR32 Neuroblastoma cells.) combined with an excellent kinetic solubility (> 200 μM).
体内活性
In blood plasma of mice having received a daily injection of compound UAMC-3203 over a period of 4 weeks, Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), LDH, creatine kinase (CK), creatinine, urea and troponin T levels were all comparable to background values detected in control mice.
细胞实验
In order to determine IC50-values, human neuroblastoma cells (IMR-32) were seeded in a 96-well plate at a density of 25,000 cells/well. The next day, the cells were pretreated for 1h (in triplicates) with a 1/3 dilution series of ferrostatin-1 analogues ranging from 5μM to 0.68nM and Sytox Green (1.6 μM) and a 1/2 dilution series of ferrostatin-1 analogues ranging from 200 nM to 0.78nM and Sytox Green (1.6 μM) for erastin and ferrous ammonium sulphate respectively. After stimulating the cells with erastin (10 μM) or ferrous ammonium sulphate (600 μM), the plate was transferred to a temperature- and CO2-controled FLUOstar Omega fluorescence plate reader. Sytox Green intensity was measured after 13h using an excitation filter of 485 nm and an emission filter of 520 nm. In each setup, Triton-X100 (0.05%) was used to induce lyses of the cells in 6 wells/plate, and was used as 100% cell death reference. The percentage of the cell death was calculated by the formula ((AVG[erastin] - AVG[background]) /(AVG[Triton-X100] - AVG[background])) × 100. Cell death percentage was plotted in GraphPad Prism 6, and IC50-values were calculated using a sigmoidal dose-response (variable slope) curve.
动物实验
Vehicle solution (2% DMSO) or compound was administered daily at a concentration of 2 mM (in 0.9% NaCl containing 2% DMSO; 200 μL / 20 g body weight) by intraperitoneal injection. Body temperature and weight were monitored daily. On day 28 the mice were anesthetized with isoflurane and blood was sampled. Hereafter, mice were sacrificed by cervical dislocation. ALT, AST and LDH levels in plasma were measured. CK, creatinine, urea and troponin T were determined.
别名UAMC3203, UAMC 3203
化学信息
分子量471.66
分子式C25H37N5O2S
CAS No.2271358-64-4
SmilesN(C1=C(NCC2=CC=CC=C2)C=C(S(NCCN3CCNCC3)(=O)=O)C=C1)C4CCCCC4
密度1.214 g/cm3 (Predicted)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 50 mg/mL (106.01 mM)
溶液配制表
1mg5mg10mg50mg
1 mM2.1202 mL10.6009 mL21.2017 mL106.0086 mL
5 mM0.4240 mL2.1202 mL4.2403 mL21.2017 mL
10 mM0.2120 mL1.0601 mL2.1202 mL10.6009 mL
20 mM0.1060 mL0.5300 mL1.0601 mL5.3004 mL
50 mM0.0424 mL0.2120 mL0.4240 mL2.1202 mL
100 mM0.0212 mL0.1060 mL0.2120 mL1.0601 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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