Glutamate-5-kinase-IN-1

Name: Glutamate-5-kinase-IN-1
Brand: TargetMol
SKU: T60693
Rating: 4.5 (1 reviews)

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产品编号 T60693

Glutamate-5-kinase-IN-1 (compound 50) 是谷氨酸-5-激酶 (G5K)的有效抑制剂，它通过改变 ATP 结合位点构象发挥抑制作用，其抑制浓度为 4.1 μM。Glutamate-5-kinase-IN-1 具有研究抗结核的潜力

Glutamate-5-kinase-IN-1

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产品编号 T60693

规格	价格	库存
25 mg	¥ 10,600	10-14周
50 mg	¥ 13,800	10-14周
100 mg	¥ 17,500	10-14周

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产品介绍

生物活性

产品描述

Glutamate-5-kinase-IN-1 (compound 50) is a potent glutamate-5-kinase (G5K) inhibitor which acts by altering the ATP binding site architecture for enzyme recognition (MIC = 4.1 μM). Glutamate-5-kinase-IN-1 has the potential for anti-TB research [1].

体外活性

Glutamate-5-kinase-IN-1 (compound 50) (40 μM) inhibits G5K activity with an I 0.5 of 22.1 μM at 10 mM concentration of L-Glu and ATP [1]. Glutamate-5-kinase-IN-1 (5, 10, 20 μM) shows no relevant cytotoxicity in HepG2 cells [1]. Glutamate-5-kinase-IN-1 (120 μM) causes a substantial increase in the Km app for ATP at constant concentrations of L-Glu (150 mM, 300 mM and 600 mM) and ATP (10 mM) [1].