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VER-49009 (CCT 129397) 是一种有效的 Hsp90 抑制剂,IC50值为 25 nM,Kd 值为 78 nM。
VER-49009 (CCT 129397) 是一种有效的 Hsp90 抑制剂,IC50值为 25 nM,Kd 值为 78 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 326 | 现货 | |
5 mg | ¥ 948 | 现货 | |
10 mg | ¥ 1,610 | 现货 | |
25 mg | ¥ 2,690 | 现货 | |
50 mg | ¥ 3,850 | 现货 | |
100 mg | ¥ 5,270 | 现货 | |
200 mg | ¥ 7,080 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 828 | 现货 |
产品描述 | VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM). |
靶点活性 | HSP90:25 nM, HSP90:78 nM(kd) |
体外活性 | VER-49009 抑制肝星状细胞系CFSC细胞的增殖,并且两者均在CFSC细胞中诱导了G2期阻滞[1]。 |
体内活性 | 经VER-49009处理后,可在最后一剂后3小时和8小时明显减少ERBB2的表达,在24小时时受试蛋白水平恢复正常,这一结果在携带已充分建立的OVCAR3人类卵巢积液肿瘤的无胸腺小鼠中得到验证[2]。 |
激酶实验 | Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe. |
细胞实验 | Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference) |
别名 | CCT 129397 |
分子量 | 387.82 |
分子式 | C19H18ClN3O4 |
CAS No. | 558640-51-0 |
Smiles | CCNC(=O)c1n[nH]c(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O |
密度 | 1.379 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (257.85 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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