NHC-diphosphate

Name: NHC-diphosphate
Brand: TargetMol
SKU: T36880
Price: 378 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T36880Cas号 39023-73-9

NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1].

NHC-diphosphate

还可以

产品编号 T36880Cas号 39023-73-9

规格	价格	库存
1 mg	¥ 3,045	期货
5 mg	¥ 6,447	期货
10 mg	¥ 9,687	期货

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产品介绍

生物活性

产品描述	NHC-diphosphate, a phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its diphosphate form[1], serves as a potent antiviral agent. As a pyrimidine ribonucleoside, NHC effectively counters the replication of Venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV), and hepatitis C virus (HCV)[1].
体外活性	Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate can be observed, while NHC-triphosphate remains the most abundant metabolite.[1].

化学信息

分子量	419.176
分子式	C₉H₁₅N₃O₁₂P₂
CAS No.	39023-73-9

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 160 mg/mL (381.70 mM)

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.3856 mL	11.9282 mL	23.8563 mL	119.2816 mL
5 mM	0.4771 mL	2.3856 mL	4.7713 mL	23.8563 mL
10 mM	0.2386 mL	1.1928 mL	2.3856 mL	11.9282 mL
20 mM	0.1193 mL	0.5964 mL	1.1928 mL	5.9641 mL
50 mM	0.0477 mL	0.2386 mL	0.4771 mL	2.3856 mL
100 mM	0.0239 mL	0.1193 mL	0.2386 mL	1.1928 mL