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ML241 是一种有效且选择性的 p97 ATPase 抑制剂。
ML241 是一种有效且选择性的 p97 ATPase 抑制剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 760 | 1-2周 | |
10 mg | ¥ 1,216 | 1-2周 | |
25 mg | ¥ 2,680 | 1-2周 | |
50 mg | ¥ 4,536 | 1-2周 |
产品描述 | ML241 is a potent and selective inhibitors of p97 ATPase. |
激酶实验 | EPZ015666 is serially diluted threefold from 1,000 to 0.051 nM and spotted into a 384-well polypropylene V-bottom microplate. 3H-SAM is serially diluted twofold in assay buffer for a seven-point dilution series with a top concentration of 700 nM (final assay concentration). Reactions are initiated by the addition of 4 nM enzyme and 40 nM peptide (final assay concentrations for both). Reactions are incubated for 60 min and quenched by the addition of 10 μL per well of 600 μM unlabeled SAM in assay buffer (final assay concentration). For the peptide competition, EPZ015666 is serially diluted threefold from 1,000 to 0.051 nM and spotted into a 384-well polypropylene V-bottom microplate. Peptide is serially diluted twofold in assay buffer for a seven-point dilution series with a top concentration of 480 nM (final assay concentration). Reactions are initiated by the addition of 4 nM enzyme and 75 nM 3H-SAM (final assay concentrations for both). Reactions are incubated for 60 min, and the reactions are quenched by the addition of 10 μL per well of 600 μM unlabeled SAM in assay buffer (final assay concentration)[1]. |
分子量 | 372.46 |
分子式 | C23H24N4O |
CAS No. | 1346528-06-0 |
Smiles | C(Nc1nc(nc2CCCCc12)N1CCOc2ccccc12)c1ccccc1 |
密度 | 1.258 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 10 mM | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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