IDO1-IN-7

Name: IDO1-IN-7
Brand: TargetMol
SKU: T39888
Rating: 4.5 (1 reviews)

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产品编号 T39888Cas号 2351199-98-7

别名 IDO1-IN-7

IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.

IDO1-IN-7

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产品编号 T39888 别名 IDO1-IN-7Cas号 2351199-98-7

规格	价格	库存	数量
25 mg	¥ 10,600	6-8周

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产品描述	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
靶点活性	IDO1 (SKOV3 cells):6.1 nM (IC50)
体外活性	IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC 50 of 330 nM[1]. IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity[1]. IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC 50 =14,000 nM)[1].
体内活性	IDO1-IN-7 (10 mg/kg; p.o.) shows C max =10.0 μM, AUC 0-8 h =27.1 μMh, t 1/2 =1.4 h in mouse[1]. Animal Model: Mouse[1]Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: Oral administration Result: C max (10.0 μM), AUC 0-8 h (27.1 μMh), t 1/2 (1.4 h)
别名	IDO1-IN-7