SNT-207707

Name: SNT-207707
Brand: TargetMol
SKU: T12944
Rating: 4.5 (1 reviews)

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产品编号 T12944Cas号 1064662-40-3

SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).

SNT-207707

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产品编号 T12944Cas号 1064662-40-3

SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor).
靶点活性	MC-4 (binding):8 nM , MC-4 (function):5 nM
体外活性	SNT-207707 binds to MC-4 receptor with an affinity of 8 nM, and has over 200-fold selectivity vs. MC-3 and MC-5. SNT207858 is a 22 nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5.
体内活性	food intake of the mice distinctly increased by SNT-207707(Single subcutaneous injection of 20 mg/kg). Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss.

化学信息

分子量	550.18
分子式	C₃₂H₄₄ClN₅O
CAS No.	1064662-40-3
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 250 mg/mL (454.40 mM)

MEthanol: 250 mg/mL (454.40 mM), Sonication is recommended.

溶液配制表

DMSO/MEthanol

	1mg	5mg	10mg	50mg
1 mM	1.8176 mL	9.0879 mL	18.1759 mL	90.8793 mL
5 mM	0.3635 mL	1.8176 mL	3.6352 mL	18.1759 mL
10 mM	0.1818 mL	0.9088 mL	1.8176 mL	9.0879 mL
20 mM	0.0909 mL	0.4544 mL	0.9088 mL	4.5440 mL
50 mM	0.0364 mL	0.1818 mL	0.3635 mL	1.8176 mL
100 mM	0.0182 mL	0.0909 mL	0.1818 mL	0.9088 mL