AZ7976 (Compound 42), a potent and highly selective agonist for Relaxin Family Peptide Receptor 1 (RXFP1) with a pEC 50 value greater than 10.5, operates through an allosteric mechanism to enhance RXFP1's cAMP signaling, which physiologically elevates heart rate. This property makes AZ7976 a valuable tool in cardiovascular disease research [1].

化合物AZ7976（静脉注射; 初次给药 1.5 mg/kg; 静脉滴注; 连续给药 9.0 mg/kg）显著增加大鼠的心率，并引起平均动脉血压升高[1]。药代动力学分析[1]: 路径剂量 (μmol/kg) Vdss (L/kg) Cl (mL/min/kg) t 1/2 (h) 口服剂量 (μmol/kg) F (%) i.v. 0.73 2.3 38 2.9 1.46 11。 动物模型：Sprague-Dawley大鼠[1]。剂量：初始 1.5 mg/kg，持续 9.0 mg/kg。给药：静脉注射; 静脉滴注。结果：导致大鼠心率显著增加和平均动脉血压上升，与RXFP1受体激活后相似的反应。