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PF-06305591 dihydrate 是具有出色的临床前体外 ADME 和安全性的,电压门控钠通道 NaV1.8的高选择性阻断剂 (IC50 = 15 nM)。
PF-06305591 dihydrate 是具有出色的临床前体外 ADME 和安全性的,电压门控钠通道 NaV1.8的高选择性阻断剂 (IC50 = 15 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | ¥ 15,366 | 10-14周 |
产品描述 | PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME and safety profile [1]. |
体外活性 | PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability [1]. |
体内活性 | PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC 50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain [1]. |
分子量 | 310.39 |
分子式 | C15H26N4O3 |
存储 | Shipping with blue ice. |
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