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HSD17B13-IN-19 (compound 16) 作为羟基类固醇 17?-脱氢酶13 (HSD17B13) (hydroxysteroid 17?-dehydrogenase 13 (HSD17B13)) 的有效抑制剂, 在针对雌二醇和白三烯 B3 两种底物的测试中展示了出色的效果,其IC50值分别小于 0.1 μM 和小于 1 μM。该化合物在非酒精性脂肪肝疾病 (NAFLD) 包括 NASH(非酒精性脂肪性肝炎)的相关研究中显示了其关键作用。
HSD17B13-IN-19 (compound 16) 作为羟基类固醇 17?-脱氢酶13 (HSD17B13) (hydroxysteroid 17?-dehydrogenase 13 (HSD17B13)) 的有效抑制剂, 在针对雌二醇和白三烯 B3 两种底物的测试中展示了出色的效果,其IC50值分别小于 0.1 μM 和小于 1 μM。该化合物在非酒精性脂肪肝疾病 (NAFLD) 包括 NASH(非酒精性脂肪性肝炎)的相关研究中显示了其关键作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1]. |
分子量 | 442.5 |
分子式 | C23H23FN2O4S |
CAS No. | 2758802-17-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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