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BAA473 是胆汁酸类似物,是一种强效的吡喃类炎症小体激活剂。BAA473可通过激活髓样和肠上皮细胞中的炎症小体来诱导白细胞介素( IL-18 )的分泌。
BAA473 是胆汁酸类似物,是一种强效的吡喃类炎症小体激活剂。BAA473可通过激活髓样和肠上皮细胞中的炎症小体来诱导白细胞介素( IL-18 )的分泌。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | |
50 mg | ¥ 13,800 | 10-14周 | |
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | BAA473 is a bile acid analog that is a potent activator of the pyrin inflammasome. BAA473 can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells [1]. |
体外活性 | BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces LPS-primed cell death in THP-1-Cas9 cells. [1]. Cell Viability Assay [1] Cell Line: THP-1-Cas9 cells Concentration: 0 μM, 0.1 μM, 0.4 μM, 1.2 μM, 3.7 μM, 11 μM, 33 μM Incubation Time: 24 hours Result: Induced cell death. |
分子量 | 574.87 |
分子式 | C36H62O5 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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