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TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 22,700 | 10-14周 | |
50 mg | ¥ 30,300 | 10-14周 | |
100 mg | ¥ 39,500 | 10-14周 |
产品描述 | TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (IC50=1.9 nM, reporter gene IC50=6.1 nM). |
靶点活性 | RORγt, binding IC50:1.9 nM , RORγt, reporter gene IC50:6.1 nM |
体内活性 | In mice with IL-23-induced cytokine expression model, TAK-828F (0.3, 1, and 3 mg/kg; orally administered; b.i.d.; 28 days; ) shows robust and dose-dependent inhibition of IL-17A expression with an ED80 of 0.5 mg/kg. |
分子量 | 509.57 |
分子式 | C28H32FN3O5 |
CAS No. | 1854901-94-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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