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EGFR-IN-134 (compound 3f) 为三唑并[3,4-a]异喹啉化合物,表现出0.023 µM的EGFR抑制作用。该物质能够促发细胞凋亡和坏死,同时在G2/M及pre-G1阶段引发细胞周期阻滞。通过下调Bcl2及上调p53、Bax以及caspases 3、8和9,EGFR-IN-134 显著增强了其抗增殖及抗癌属性。
EGFR-IN-134 (compound 3f) 为三唑并[3,4-a]异喹啉化合物,表现出0.023 µM的EGFR抑制作用。该物质能够促发细胞凋亡和坏死,同时在G2/M及pre-G1阶段引发细胞周期阻滞。通过下调Bcl2及上调p53、Bax以及caspases 3、8和9,EGFR-IN-134 显著增强了其抗增殖及抗癌属性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | EGFR-IN-134 (compound 3f) is a triazolo[3,4-a]quinoline derivative and functions as a potent EGFR inhibitor with an IC50 of 0.023 µM. It induces apoptosis and necrosis in cells, and causes cell cycle arrest in the G2/M and pre-G1 phases. EGFR-IN-134 modulates the expression of apoptosis-regulating proteins by downregulating anti-apoptotic protein Bcl2 and upregulating pro-apoptotic proteins p53, Bax, and caspases 3, 8, and 9, demonstrating significant antiproliferative and anticancer activities. |
靶点活性 | EGFR:0.023μM(IC50) |
分子量 | 626.66 |
分子式 | C36H30N6O5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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